PDF(Pubmed)
Abstract：
UNASSIGNED: In the acute phase of Ebola virus disease (EVD) premature neonatal survival is extremely rare. High mortality is related to prematurity, neonatal complications of Ebola, and precarious conditions of neonatal care in underresourced ETUs. This is a case of preterm neonatal survival in the setting of acute maternal EVD infection.
UNASSIGNED: This case describes rare preterm newborn survival in the setting of an Ebola treatment unit in Eastern DRC. The neonate was born vaginally to an acutely ill 17-year-old mother who was vaccinated against Ebola virus after being identified as a contact of her father, who was a confirmed case and who did not survive his infection. This woman was admitted to an Ebola treatment unit at 32 weeks of gestation and given monoclonal antibody treatment. She gave birth vaginally, succumbing to postpartum hemorrhage 14 h after delivery. This child survived despite compounding vulnerabilities of preterm birth and maternal Ebola infection. Despite a negative test for EVD, the neonate was given a single dose of monoclonal antibody therapy in the first days of life. We believe maternal vaccination and neonatal monoclonal antibody treatment contributed to the child\'s survival. The circumstances surrounding neonatal survival in this extremely resource-limited context must be analyzed and disseminated in order to increase rates of neonatal and maternal survival in future outbreaks. Maternal and neonatal health are critical aspects of outbreak response that have been understudied and underreported leaving clinicians severely underresourced to provide life-saving care in outbreak settings. Pregnancy and childbirth do not stop in times of disease outbreak, adequate equipment and trained staff required for quality neonatal care must be considered in future outbreak responses.
UNASSIGNED: This case describes rare preterm newborn survival in the setting of an Ebola treatment unit in Eastern DRC. The neonate was born vaginally to an acutely ill 17-year-old mother who was vaccinated against Ebola virus after being identified as a contact of her father, who was a confirmed case and who did not survive his infection. This woman was admitted to an Ebola treatment unit at 32 weeks of gestation and given monoclonal antibody treatment. She gave birth vaginally, succumbing to postpartum hemorrhage 14 h after delivery. This child survived despite compounding vulnerabilities of preterm birth and maternal Ebola infection. Despite a negative test for EVD, the neonate was given a single dose of monoclonal antibody therapy in the first days of life. We believe maternal vaccination and neonatal monoclonal antibody treatment contributed to the child\'s survival. The circumstances surrounding neonatal survival in this extremely resource-limited context must be analyzed and disseminated in order to increase rates of neonatal and maternal survival in future outbreaks. Maternal and neonatal health are critical aspects of outbreak response that have been understudied and underreported leaving clinicians severely underresourced to provide life-saving care in outbreak settings. Pregnancy and childbirth do not stop in times of disease outbreak, adequate equipment and trained staff required for quality neonatal care must be considered in future outbreak responses.
摘要：
■在埃博拉病毒病（EVD）的急性期，过早的新生儿存活极为罕见。高死亡率与早产有关,埃博拉的新生儿并发症，以及资源不足的ETU中新生儿护理的不稳定状况。这是在急性母体EVD感染的情况下早产新生儿存活的情况。
■该病例描述了刚果民主共和国东部埃博拉治疗单位的罕见早产新生儿存活率。这名新生儿是由一名17岁的重症母亲阴道出生的，该母亲在被确认为与父亲接触后接种了埃博拉病毒疫苗，他是一个确诊的病例，没有在感染中幸存下来。这名妇女在妊娠32周时被送往埃博拉治疗单位，并接受了单克隆抗体治疗。她阴道分娩，产后出血14小时后死亡。尽管早产和孕产妇感染埃博拉病毒的脆弱性加剧，但这个孩子还是幸存下来。尽管对EVD的测试呈阴性，新生儿在出生后的第一天接受单剂量单克隆抗体治疗.我们认为母亲接种疫苗和新生儿单克隆抗体治疗有助于儿童的生存。在这种资源极其有限的情况下，必须分析和传播围绕新生儿生存的情况，以便在未来的疫情中提高新生儿和产妇的存活率。孕产妇和新生儿健康是疫情应对的关键方面，但研究不足和报告不足，导致临床医生在疫情环境中提供救生护理的资源严重不足。怀孕和分娩不会在疾病爆发时停止，在未来的疫情应对措施中，必须考虑到优质新生儿护理所需的足够设备和训练有素的工作人员。
■该病例描述了刚果民主共和国东部埃博拉治疗单位的罕见早产新生儿存活率。这名新生儿是由一名17岁的重症母亲阴道出生的，该母亲在被确认为与父亲接触后接种了埃博拉病毒疫苗，他是一个确诊的病例，没有在感染中幸存下来。这名妇女在妊娠32周时被送往埃博拉治疗单位，并接受了单克隆抗体治疗。她阴道分娩，产后出血14小时后死亡。尽管早产和孕产妇感染埃博拉病毒的脆弱性加剧，但这个孩子还是幸存下来。尽管对EVD的测试呈阴性，新生儿在出生后的第一天接受单剂量单克隆抗体治疗.我们认为母亲接种疫苗和新生儿单克隆抗体治疗有助于儿童的生存。在这种资源极其有限的情况下，必须分析和传播围绕新生儿生存的情况，以便在未来的疫情中提高新生儿和产妇的存活率。孕产妇和新生儿健康是疫情应对的关键方面，但研究不足和报告不足，导致临床医生在疫情环境中提供救生护理的资源严重不足。怀孕和分娩不会在疾病爆发时停止，在未来的疫情应对措施中，必须考虑到优质新生儿护理所需的足够设备和训练有素的工作人员。
