PDF(Pubmed)
Abstract：
UNASSIGNED: Adolescent idiopathic scoliosis (AIS) is characterized by deranged bone and muscle qualities, which are important prognostic factors for curve progression. This retrospective case-control study aims to investigate whether the baseline muscle parameters, in addition to the bone parameters, could predict curve progression in AIS.
UNASSIGNED: The study included a cohort of 126 female patients diagnosed with AIS who were between the ages of 12 and 14 years old at their initial clinical visit. These patients were longitudinally followed up every 6 months (average 4.08 years) until they reached skeletal maturity. The records of these patients were thoroughly reviewed as part of the study. The participants were categorized into two sub-groups: the progressive AIS group (increase in Cobb angle of ≥6°) and the stable AIS group (increase in Cobb angle <6°). Clinical and radiological assessments were conducted on each group.
UNASSIGNED: Cobb angle increase of ≥6° was observed in 44 AIS patients (34.9%) prior to skeletal maturity. A progressive AIS was associated with decreased skeletal maturity and weight, lower trunk lean mass (5.7%, p = 0.027) and arm lean mass (8.9%, p < 0.050), weaker dominant handgrip strength (8.8%, p = 0.027), deranged cortical compartment [lower volumetric bone mineral density (vBMD) by 6.5%, p = 0.002], and lower bone mechanical properties [stiffness and estimated failure load lowered by 13.2% (p = 0.005) and 12.5% (p = 0.004)]. The best cut-off threshold of maximum dominant handgrip strength is 19.75 kg for distinguishing progressive AIS from stable AIS (75% sensitivity and 52.4% specificity, p = 0.011).
UNASSIGNED: Patients with progressive AIS had poorer muscle and bone parameters than patients with stable AIS. The implementation of a cut-off threshold in the baseline dominant handgrip strength could potentially be used as an additional predictor, in addition to bone parameters, for identifying individuals with AIS who are at higher risk of experiencing curve progression.
UNASSIGNED: The study included a cohort of 126 female patients diagnosed with AIS who were between the ages of 12 and 14 years old at their initial clinical visit. These patients were longitudinally followed up every 6 months (average 4.08 years) until they reached skeletal maturity. The records of these patients were thoroughly reviewed as part of the study. The participants were categorized into two sub-groups: the progressive AIS group (increase in Cobb angle of ≥6°) and the stable AIS group (increase in Cobb angle <6°). Clinical and radiological assessments were conducted on each group.
UNASSIGNED: Cobb angle increase of ≥6° was observed in 44 AIS patients (34.9%) prior to skeletal maturity. A progressive AIS was associated with decreased skeletal maturity and weight, lower trunk lean mass (5.7%, p = 0.027) and arm lean mass (8.9%, p < 0.050), weaker dominant handgrip strength (8.8%, p = 0.027), deranged cortical compartment [lower volumetric bone mineral density (vBMD) by 6.5%, p = 0.002], and lower bone mechanical properties [stiffness and estimated failure load lowered by 13.2% (p = 0.005) and 12.5% (p = 0.004)]. The best cut-off threshold of maximum dominant handgrip strength is 19.75 kg for distinguishing progressive AIS from stable AIS (75% sensitivity and 52.4% specificity, p = 0.011).
UNASSIGNED: Patients with progressive AIS had poorer muscle and bone parameters than patients with stable AIS. The implementation of a cut-off threshold in the baseline dominant handgrip strength could potentially be used as an additional predictor, in addition to bone parameters, for identifying individuals with AIS who are at higher risk of experiencing curve progression.
摘要：
■青少年特发性脊柱侧凸（AIS）的特征是骨骼和肌肉质量紊乱，这是曲线进展的重要预后因素。这项回顾性病例对照研究旨在调查基线肌肉参数是否，除了骨骼参数，可以预测AIS中的曲线进展。
■该研究包括126名诊断为AIS的女性患者的队列，这些患者在初次临床就诊时年龄在12至14岁之间。每6个月（平均4.08年）对这些患者进行纵向随访，直至达到骨骼成熟。作为研究的一部分，对这些患者的记录进行了彻底审查。将参与者分为两个亚组：渐进性AIS组（Cobb角增加≥6°）和稳定AIS组（Cobb角增加<6°）。对每组进行临床和放射学评估。
■在骨骼成熟之前的44例AIS患者（34.9％）中观察到Cobb角增加≥6°。进行性AIS与骨骼成熟度和体重下降有关，较低的躯干瘦肉质量(5.7%，p=0.027)和臂瘦质量(8.9%，p<0.050),较弱的显性握力(8.8%，p=0.027),紊乱的皮质室[降低体积骨矿物质密度（vBMD）6.5％，p=0.002],和较低的骨机械性能[刚度和估计的破坏载荷降低了13.2％（p=0.005）和12.5％（p=0.004）]。最大优势握力的最佳截止阈值为19.75kg，用于区分进行性AIS和稳定AIS（75％的灵敏度和52.4％的特异性，p=0.011)。
■进行性AIS患者的肌肉和骨骼参数比稳定性AIS患者差。在基线主导握力中实施截止阈值可以潜在地用作额外的预测器。除了骨骼参数，用于识别AIS患者经历曲线进展的风险较高。
■该研究包括126名诊断为AIS的女性患者的队列，这些患者在初次临床就诊时年龄在12至14岁之间。每6个月（平均4.08年）对这些患者进行纵向随访，直至达到骨骼成熟。作为研究的一部分，对这些患者的记录进行了彻底审查。将参与者分为两个亚组：渐进性AIS组（Cobb角增加≥6°）和稳定AIS组（Cobb角增加<6°）。对每组进行临床和放射学评估。
■在骨骼成熟之前的44例AIS患者（34.9％）中观察到Cobb角增加≥6°。进行性AIS与骨骼成熟度和体重下降有关，较低的躯干瘦肉质量(5.7%，p=0.027)和臂瘦质量(8.9%，p<0.050),较弱的显性握力(8.8%，p=0.027),紊乱的皮质室[降低体积骨矿物质密度（vBMD）6.5％，p=0.002],和较低的骨机械性能[刚度和估计的破坏载荷降低了13.2％（p=0.005）和12.5％（p=0.004）]。最大优势握力的最佳截止阈值为19.75kg，用于区分进行性AIS和稳定AIS（75％的灵敏度和52.4％的特异性，p=0.011)。
■进行性AIS患者的肌肉和骨骼参数比稳定性AIS患者差。在基线主导握力中实施截止阈值可以潜在地用作额外的预测器。除了骨骼参数，用于识别AIS患者经历曲线进展的风险较高。
