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Abstract：
Bone metabolic homeostasis is dependent on coupled bone formation dominated by osteoblasts and bone resorption dominated by osteoclasts, which is a process of dynamic balance between bone formation and bone resorption. Notably, the formation of bone relies on the development of bone vasculature. Previous studies have shown that oxidative stress caused by disturbances in the antioxidant system of the whole organism is an important factor affecting bone metabolism. The increase in intracellular reactive oxygen species can lead to disturbances in bone metabolism, which can initiate multiple bone diseases, such as osteoporosis and osteoarthritis. Traditional Chinese medicine is considered to be an effective antioxidant. Cumulative evidence shows that the traditional Chinese medicine can alleviate oxidative stress-mediated bone metabolic disorders by modulating multiple signaling pathways, such as Nrf2/HO-1 signaling, PI3K/Akt signaling, Wnt/β-catenin signaling, NF-κB signaling, and MAPK signaling. In this paper, the potential mechanisms of traditional Chinese medicine to regulate bone me-tabolism through oxidative stress is summarized to provide direction and theoretical basis for future research related to the treatment of bone diseases with traditional Chinese medicine.
摘要：
骨代谢稳态依赖于以成骨细胞为主的耦合骨形成和以破骨细胞为主的骨吸收。骨形成和骨吸收之间的动态平衡过程。值得注意的是,骨的形成依赖于骨脉管系统的发育。先前的研究表明，由整个生物体抗氧化系统的紊乱引起的氧化应激是影响骨代谢的重要因素。细胞内活性氧的增加可导致骨代谢紊乱,可以引发多种骨骼疾病，如骨质疏松症和骨关节炎。中药被认为是一种有效的抗氧化剂。累积证据表明,中药可通过调节多种信号通路缓解氧化应激介导的骨代谢紊乱,例如Nrf2/HO-1信令，PI3K/Akt信令,Wnt/β-连环蛋白信号传导，NF-κB信号,和MAPK信号。在本文中,总结了中医药通过氧化应激调节骨病的潜在机制，为今后中医药治疗骨病的相关研究提供方向和理论依据。
