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Abstract：
Background: The utilization of antibiotic adjuvants presents a promising strategy for addressing bacterial resistance. Recently, the development of antibiotic adjuvants has attracted considerable attention from researchers in academia and industry. This study aimed to identify the most influential publications on antibiotic adjuvants and elucidate the hotspots and research trends in this field. Method: Original articles and reviews related to antibiotic adjuvants were retrieved from the Web of Science Core Collection database. The top 100 highly cited publications were selected and the visual analyses of publication outputs, countries, institutions, authors, journals, and keywords were conducted using Excel, VOSviewer, or CtieSpace software tools. Results: The top 100 cited publications concerning antibiotic adjuvants spanned the years 1977-2020, with citation counts ranging from 174 to 2,735. These publications encompassed 49 original articles and 51 reviews. The journal \"Antimicrobial Agents and Chemotherapy\" accounted for the highest number of publications (12%). The top 100 cited publications emanated from 39 countries, with the United States leading in production. Institutions in Canada and the United States exhibited the most substantial contributions to these highly cited publications. A total of 526 authors participated in these studies, with Robert E.W. Hancock, Laura J. V. Piddock, Xian-Zhi Li, Hiroshi Nikaido, and Olga Lomovskaya emerging as the most frequently nominated authors. The most common keywords included \"E. coli\", \"P. aeruginosa\", \"S. aureus\", \"in-vitro activity\", \"antimicrobial peptide\", \"efflux pump inhibitor\" \"efflux pump\", \"MexAB-OprM\" and \"mechanism\". These keywords underscored the hotspots of bacterial resistance mechanisms and the development of novel antibiotic adjuvants. Conclusion: Through the bibliometric analysis, this study identified the top 100 highly cited publications on antibiotic adjuvants. Moreover, the findings offered a comprehensive understanding of the characteristics and frontiers in this field.
摘要：
背景：抗生素佐剂的利用为解决细菌耐药性提供了有希望的策略。最近,抗生素佐剂的开发引起了学术界和工业界研究人员的极大关注。本研究旨在确定有关抗生素佐剂的最具影响力的出版物，并阐明该领域的热点和研究趋势。方法：从WebofScienceCoreCollection数据库中检索与抗生素佐剂相关的原始文章和评论。选择了前100名高引用出版物，并对出版物产出进行了可视化分析，国家,机构,作者,期刊,关键字是使用Excel进行的，VOSviewer,或CtieSpace软件工具。结果：关于抗生素佐剂的前100篇被引用的出版物跨越了1977-2020年，引用次数从174到2,735不等。这些出版物包括49篇原创文章和51篇评论。《抗菌药物和化疗》杂志的出版物数量最高（12%）。引用最多的100种出版物来自39个国家，美国在生产方面处于领先地位。加拿大和美国的机构对这些高引用出版物的贡献最大。共有526位作者参与了这些研究，罗伯特·E·W·汉考克，LauraJ.V.Piddock,李贤智,HiroshiNikaido,和OlgaLomoovskaya成为最常被提名的作者。最常见的关键词包括\"E.大肠杆菌\“，\"P.铜绿假单胞菌“，\"S.金黄色葡萄球菌“，“体外活性”，“抗菌肽”，\"外排泵抑制剂\"\"外排泵\",\"MexAB-OprM\"和\"机制\"。这些关键词强调了细菌耐药机制的热点和新型抗生素佐剂的开发。结论:通过文献计量分析,这项研究确定了前100名被高度引用的抗生素佐剂出版物。此外，这些发现提供了对该领域特征和前沿的全面了解。
