PDF(Pubmed)
Abstract：
Despite advances in antiemetics and protocolized postoperative nausea vomiting (PONV) management, it remains one of the most common postoperative adverse events. In patients who developed PONV despite antiemetic prophylaxis, giving a rescue treatment from the same class of medication is known to be of limited efficacy. Given the widespread use of 5-HT3 antagonists as PONV prophylaxis, another class of effective intravenous rescue antiemetic is in dire need, especially when prophylaxis fails, and rescue medication is utilized. Dopamine antagonists were widely used for the treatment of PONV but have fallen out of favor due to some of their side effect profiles. Amisulpride was first designed as an antipsychotic medication but was found to have antiemetic properties. Here we will review the historical perspective on the use of dopamine receptor antagonist antiemetics, as well as the evidence on the efficacy and safety of amisulpride.
摘要：
尽管在止吐药和原生质化术后恶心呕吐（PONV）管理方面取得了进展，它仍然是最常见的术后不良事件之一.尽管有止吐预防，但仍发展为PONV的患者，从同类药物中给予抢救治疗是已知的疗效有限。鉴于广泛使用5-HT3拮抗剂作为PONV预防，迫切需要另一类有效的静脉内抢救止吐剂，尤其是当预防失败时，并利用救护药物。多巴胺拮抗剂广泛用于治疗PONV,但由于它们的一些副作用谱而已经失宠。氨磺必利最初被设计为抗精神病药物，但被发现具有止吐特性。在这里，我们将回顾使用多巴胺受体拮抗剂止吐药的历史观点，以及氨磺必利疗效和安全性的证据。
