PDF(Pubmed)
Abstract：
UNASSIGNED: Systemic inflammation index (SII: neutrophil count * platelet count/lymphocyte count) is a new inflammatory marker that can reflect the degree of systemic inflammatory response after coronary artery disease (CAD). However, the predictive value of the SII for clinical prognosis in patients with initially diagnosed acute coronary syndrome (ACS) has yet to be thoroughly studied.
UNASSIGNED: Patients with initially diagnosed ACS who underwent primary coronary angiography in our hospital from January 2019 to April 2021 were included in this study. 757 patients with ACS who underwent primary coronary angiography were enrolled. According to the baseline SII level, the patients were divided into a high SII group and a low SII group. The primary endpoint was major cardiovascular events (MACEs), defined as cardiac death, non-fatal myocardial infarction (MI), and non-fatal stroke.
UNASSIGNED: At a median follow-up of 33.9 months, 140 (18.5%) MACEs were recorded. Receiver operating characteristic (ROC) curve analysis showed that SII\'s best cut-off value for predicting MACEs was 713.9*109/L. Kaplan-Meier survival curve analysis showed that the survival rate of the low SII group was higher than the high SII group (P<0.001). Compared with the low SII group, the risk of MACEs was significantly increased in the high SII group (89 cases (33.3%) vs.51 patients (10.4%), P<0.001). Univariate and multivariate Cox regression analysis manifested that high SII level was independently associated with the occurrence of MACEs in patients with ACS undergoing primary coronary angiography (adjusted hazard ratio [HR]: 2.915, 95% confidence interval (CI%): 1.830-4.641, P<0.001). Adding SII to the conventional risk factor model improved the predictive value of MACEs.
UNASSIGNED: This study showed that elevated SII was associated with adverse cardiovascular prognosis in patients with ACS undergoing primary coronary angiography, making SII a valuable predictor of poor prognosis in patients with ACS undergoing primary coronary angiography.
UNASSIGNED: Patients with initially diagnosed ACS who underwent primary coronary angiography in our hospital from January 2019 to April 2021 were included in this study. 757 patients with ACS who underwent primary coronary angiography were enrolled. According to the baseline SII level, the patients were divided into a high SII group and a low SII group. The primary endpoint was major cardiovascular events (MACEs), defined as cardiac death, non-fatal myocardial infarction (MI), and non-fatal stroke.
UNASSIGNED: At a median follow-up of 33.9 months, 140 (18.5%) MACEs were recorded. Receiver operating characteristic (ROC) curve analysis showed that SII\'s best cut-off value for predicting MACEs was 713.9*109/L. Kaplan-Meier survival curve analysis showed that the survival rate of the low SII group was higher than the high SII group (P<0.001). Compared with the low SII group, the risk of MACEs was significantly increased in the high SII group (89 cases (33.3%) vs.51 patients (10.4%), P<0.001). Univariate and multivariate Cox regression analysis manifested that high SII level was independently associated with the occurrence of MACEs in patients with ACS undergoing primary coronary angiography (adjusted hazard ratio [HR]: 2.915, 95% confidence interval (CI%): 1.830-4.641, P<0.001). Adding SII to the conventional risk factor model improved the predictive value of MACEs.
UNASSIGNED: This study showed that elevated SII was associated with adverse cardiovascular prognosis in patients with ACS undergoing primary coronary angiography, making SII a valuable predictor of poor prognosis in patients with ACS undergoing primary coronary angiography.
摘要：
■全身炎症指数（SII：中性粒细胞计数*血小板计数/淋巴细胞计数）是一种新的炎症标志物，可反映冠状动脉疾病（CAD）后全身炎症反应的程度。然而,SII对最初诊断为急性冠脉综合征(ACS)患者临床预后的预测价值尚待深入研究.
■从2019年1月至2021年4月在我院接受了原发性冠状动脉造影的初始诊断为ACS的患者被纳入本研究。纳入757例接受原发性冠状动脉造影的ACS患者。根据基线SII水平，将患者分为高SII组和低SII组.主要终点是主要心血管事件（MACEs），定义为心脏死亡，非致死性心肌梗死(MI),和非致命性中风。
■中位随访时间为33.9个月，记录140（18.5%）MACE。受试者工作特征(ROC)曲线分析显示,SII预测MACE的最佳临界值为713.9*109/L。Kaplan-Meier生存曲线分析显示,低SII组生存率高于高SII组(P<0.001)。与低SII组相比，高SII组的MACEs风险显著增加(89例(33.3%),51例(10.4%),P<0.001)。单因素和多因素Cox回归分析显示，高SII水平与接受原发性冠状动脉造影的ACS患者发生MACEs独立相关（校正风险比[HR]：2.915，95%置信区间（CI％）：1.830-4.641，P<0.001）。在常规风险因素模型中加入SII提高了MACE的预测价值。
■这项研究表明，在接受原发性冠状动脉造影的ACS患者中，SII升高与不良心血管预后相关，使SII成为接受原发性冠状动脉造影的ACS患者预后不良的有价值的预测指标。
■从2019年1月至2021年4月在我院接受了原发性冠状动脉造影的初始诊断为ACS的患者被纳入本研究。纳入757例接受原发性冠状动脉造影的ACS患者。根据基线SII水平，将患者分为高SII组和低SII组.主要终点是主要心血管事件（MACEs），定义为心脏死亡，非致死性心肌梗死(MI),和非致命性中风。
■中位随访时间为33.9个月，记录140（18.5%）MACE。受试者工作特征(ROC)曲线分析显示,SII预测MACE的最佳临界值为713.9*109/L。Kaplan-Meier生存曲线分析显示,低SII组生存率高于高SII组(P<0.001)。与低SII组相比，高SII组的MACEs风险显著增加(89例(33.3%),51例(10.4%),P<0.001)。单因素和多因素Cox回归分析显示，高SII水平与接受原发性冠状动脉造影的ACS患者发生MACEs独立相关（校正风险比[HR]：2.915，95%置信区间（CI％）：1.830-4.641，P<0.001）。在常规风险因素模型中加入SII提高了MACE的预测价值。
■这项研究表明，在接受原发性冠状动脉造影的ACS患者中，SII升高与不良心血管预后相关，使SII成为接受原发性冠状动脉造影的ACS患者预后不良的有价值的预测指标。
