PDF(Pubmed)
Abstract：
The capability of the urinary tract to undergo metaplastic changes such as squamous, intestinal, glandular, mucinous, or ciliated epithelium in renal pelvis has been previously reported, which hypothetically is due to the mechanical irritation of the transitional epithelium. However, transitional metaplasia is a rare presentation in the collecting ducts. The aim of this paper was to report this type of extremely rare metaplasia and to inform pathologists that they may encounter this kind of metaplasia. A 25-year-old man, a known case of vesicoureteral reflux (VUR), referred to the Imam Reza Hospital; affiliated to the Mashhad University of Medical Sciences, for bilateral nephrectomy. Gross evaluation of bilateral nephrectomy specimens showed atrophic kidneys and dilated pelvicalyceal systems. The light microscopic evaluation showed transitional metaplasia in the background of chronic pyelonephritis, confirmed by GATA3 nuclear immunohistochemical stain. In this study, we presented a rare case of a renal collecting duct with transitional epithelial lining replacing the normal epithelium as a metaplastic change, with the hypothesis that previous medical history including VUR, or hemodialysis could be the trigger for the metaplastic change, which should be confirmed by further studies.
摘要：
泌尿道发生化生改变的能力，如鳞状，肠,腺体,粘液，或肾盂纤毛上皮先前有报道，假设这是由于过渡上皮的机械刺激。然而,过渡化生是一种罕见的表现在收集导管。本文的目的是报告这种极为罕见的化生，并告知病理学家他们可能会遇到这种化生。一个25岁的男人,一个已知的膀胱输尿管反流（VUR）病例，提到伊玛目Reza医院；隶属于马什哈德医科大学，用于双侧肾切除术。双侧肾切除术标本的总体评估显示萎缩性肾脏和扩张的骨盆系统。光镜评价显示慢性肾盂肾炎背景下的过渡性上皮化生，经GATA3核免疫组织化学染色证实。在这项研究中,我们提出了一个罕见的情况下，肾脏集合管与过渡上皮衬里取代正常上皮作为化生改变，假设以前的病史包括VUR，或者血液透析可能是化生改变的触发因素，这应该得到进一步研究的证实。
