Rapid Diagnosis of Hemophagocytic Lymphohistiocytosis Triggered by Disseminated BCG Infection in Infants With Severe Combined Immunodeficiency: Case Report.

重症联合免疫缺陷患儿播散性卡介苗感染诱发噬血细胞性淋巴组织细胞增多症的快速诊断: 病例报告.

• 影响指数: 4.423
• 发表时间: 2023 Nov
• 来源期刊: Open Forum Infect Dis
• DOI: 10.1093/ofid/ofad548
• PMID: 38023550
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Zou TT,Liao Q,Liu Y,Guo Q,Zhu Y,Wan CM

关键词: Mycobacterium bovis BCG; disseminated BCG disease; hemophagocytic lymphohistiocytosis; severe combined immunodeficiency; targeted next-generation sequencing

Abstract

Hemophagocytic lymphohistiocytosis triggered by disseminated Bacillus Calmette-Guerin infection is rare. Targeted next-generation sequencing for tuberculosis can rapidly identify different strains of Mycobacterium tuberculosis complex as well as drug resistance genes. Herein we report 2 cases of hemophagocytic lymphohistiocytosis in whom targeted next-generation sequencing rapidly identified Bacillus Calmette-Guerin as the infectious trigger.

摘要

由播散的卡介苗感染引发的噬血细胞淋巴组织细胞增多症很少见。针对结核病的靶向下一代测序可以快速鉴定不同菌株的结核分枝杆菌复合体以及耐药基因。在此，我们报告了2例噬血细胞性淋巴组织细胞增生症，其中靶向下一代测序迅速将卡介苗杆菌鉴定为感染性触发物。