PDF(Pubmed)
Abstract：
Type 2 diabetes mellitus (T2DM), a complicated metabolic disease, might be developed or exacerbated by air pollution, resulting in economic and health burden to patients. So far, limited studies have estimated associations between short-term exposure to air pollution and disease burden of T2DM in China. Hence, we aimed to estimate the associations and burden of ambient air pollutants (NO2, PM10, PM2.5, SO2, and CO) on hospital admissions (HAs) for T2DM using a time-stratified case-crossover design. Data on HAs for T2DM during 2017-2019 were collected from hospital electronic health records in nine cities in Sichuan Province using conditional poisson regression. Totally, 92,381 T2DM hospitalizations were recorded. There were significant short-term effects of NO2, PM10, PM2.5, SO2 and CO on HAs for T2DM. A 10 μg/m3 increment of NO2, PM10, PM2.5, SO2 and CO as linked with a 3.39% (95% CI: 2.26%, 4.54%), 0.33% (95% CI: 0.04%, 0.62%), 0.76% (95% CI: 0.35%, 1.16%), 12.68% (95% CI: 8.14%, 17.42%) and 79.00% (95% CI: 39.81%, 129.18%) increase in HAs for T2DM at lag 6. Stratified analyses modified by age, sex, and season showed old (≥65 years) and female patients linked with higher impacts. Using WHO\'s air quality guidelines of NO2, PM10, PM2.5, and CO as the reference, the attributable number of T2DM HAs exceeding these pollutants exposures were 786, 323, 793, and 2,127 during 2017-2019. Besides, the total medical costs of 25.83, 10.54, 30.74, and 67.78 million China Yuan were attributed to NO2, PM10, PM2.5, and CO. In conclusion, short-term exposures to air pollutants were associated with higher risks of HAs for T2DM.
摘要：
2型糖尿病(T2DM),一种复杂的代谢性疾病,空气污染可能会加剧或加剧，给患者带来经济和健康负担。到目前为止,有限的研究估计了中国短期暴露于空气污染与T2DM疾病负担之间的关联。因此，我们旨在使用时间分层病例交叉设计,估计环境空气污染物(NO2,PM10,PM2.5,SO2和CO)与T2DM住院患者(HA)的相关性和负担.使用条件泊松回归从四川省9个城市的医院电子健康档案中收集2017-2019年T2DM的HAs数据。完全正确,记录92,381例T2DM住院。NO2，PM10，PM2.5，SO2和CO对T2DM的HAs有明显的短期影响。NO2，PM10，PM2.5，SO2和CO的10μg/m3增量与3.39％（95％CI：2.26％，4.54%），0.33%（95%CI：0.04%，0.62%），0.76%（95%CI：0.35%，1.16%），12.68%（95%CI：8.14%，17.42%）和79.00%（95%CI：39.81%，129.18%）在滞后6时T2DM的HAs增加。按年龄修改的分层分析，性别,和季节显示老年（≥65岁）和女性患者与较高的影响相关。以WHO的NO2、PM10、PM2.5和CO空气质量指南为参考,在2017-2019年期间，超过这些污染物暴露的T2DMHA的可归因数量为786、323、793和2,127。此外,医疗总费用分别为25.83、10.54、30.74和6778万元人民币，分别来自NO2、PM10、PM2.5和CO。总之,短期暴露于空气污染物与T2DM的HAs风险较高相关。
