PDF(Pubmed)
Abstract：
The postoperative burden remains significant due to the possibility of prolonged hospitalization, escalated healthcare costs, and patient distress caused by postorthopedic surgical site infections (SSIs). Orthopedic surgery is likewise faced with a significant challenge posed by these conditions. A positive association has been observed between the presence of postorthopedic SSIs and heightened susceptibility to adverse health outcomes, along with elevated rates of morbidity and mortality. Systemic antibiotic prophylaxis (SAP) reduces the risk of acquiring an SSI. Closed fractures, open fractures, arthroplasty, and percutaneous fixation each possess distinct attributes that impact the data and antimicrobial therapy. When implementing SAP, it is crucial to strike a delicate equilibrium between maintaining effective antibiotic stewardship protocols and preventing the occurrence of SSIs. This practice effectively prevents both the incidence of negative consequences and the emergence of antibiotic resistance. The objective of this study was to examine the existing literature on the use of surgical antibiotic prophylaxis in orthopedic surgery and explore the potential consequences associated with the inappropriate administration of antibiotics.
摘要：
由于长期住院的可能性，术后负担仍然很大，不断升级的医疗成本，和由手术后手术部位感染（SSIs）引起的患者痛苦。骨科手术同样面临着由这些条件带来的重大挑战。已观察到手术后SSIs的存在与对不良健康结果的易感性增加之间存在正相关。随着发病率和死亡率的上升。全身性抗生素预防（SAP）降低了获得SSI的风险。闭合性骨折,开放性骨折,关节成形术,和经皮固定各自具有影响数据和抗菌治疗的不同属性。在实施SAP时，在维持有效的抗生素管理方案和防止SSIs的发生之间达成微妙的平衡是至关重要的。这种做法有效地防止了负面后果的发生和抗生素耐药性的出现。这项研究的目的是检查有关骨科手术中外科抗生素预防使用的现有文献，并探讨与不当使用抗生素相关的潜在后果。
