PDF(Pubmed)
Abstract：
Fine needle aspiration cytology (FNAC) is an established diagnostic modality today, but its utilization in skin tumors is limited by the fact that most of these lesions are small and easily accessible for clinicians to perform an excision biopsy. As a result, our knowledge of the cytological features of some of the uncommonly encountered skin tumors is still lacking. The aim of this study was to correlate the cytological features of cutaneous mixed tumors (CMTs) with histological and immunohistochemical findings in four cases of CMT in commonly and uncommonly encountered locations. We also review the recent updates highlighting the various genetic rearrangements and newer more specific immunohistochemical markers described so far. This was a retrospective study, and all the slides were taken from our departmental archives. Case 1 was a 25-year-old male who presented with a gradually increasing painless swelling over the right angle of the mouth of 1.5 years duration. Case 2 was a 45-year-old male with swelling on the right forearm for the last three years. Case 3 was a 35-year-old female with a forehead swelling of one year duration. Case 4 was a 55-year-old female with left cheek swelling for two years. On clinical examination, all four nodular swellings were predominantly in the skin/subcutaneous tissue. On cytology, all cases showed abundant chondromyxoid material with clusters of benign epithelial cells and a fair number of predominantly singly scattered myoepithelial cells. The diagnosis of all four cases was further confirmed on histopathology and immunohistochemistry, and the findings correlated well with cytology. The cytological features of CMT closely correlate with their histopathological and immunohistochemical features. Newer immunohistochemistry (IHC) marker pleomorphic adenoma gene 1 (PLAG1) may be helpful in making a definitive diagnosis of CMT on cytology and cell block preparation along with a good clinical correlation. Complete surgical excision is the treatment of choice, and recurrence is rare.
摘要：
细针抽吸细胞学（FNAC）是当今公认的诊断方式，但其在皮肤肿瘤中的应用受到以下事实的限制：这些病变中的大多数都很小，易于临床医生进行切除活检。因此,我们对一些罕见的皮肤肿瘤的细胞学特征仍然缺乏了解。这项研究的目的是将皮肤混合肿瘤（CMT）的细胞学特征与四例CMT在常见和不常见部位的组织学和免疫组织化学发现相关联。我们还回顾了最近的更新，强调了迄今为止描述的各种遗传重排和更新的更具体的免疫组织化学标记。这是一项回顾性研究,所有的幻灯片都取自我们的部门档案.病例1是一名25岁的男性，在1.5年的口腔直角上表现出逐渐增加的无痛肿胀。病例2是一名45岁的男性，在过去三年中，右前臂肿胀。病例3是一名35岁的女性，前额肿胀持续一年。病例4是一名55岁的女性，左颊肿胀两年。在临床检查中，4例结节状肿胀主要发生在皮肤/皮下组织.在细胞学上，所有病例均显示丰富的软骨粘液样物质，良性上皮细胞簇和相当数量的主要是单个分散的肌上皮细胞。所有四例病例的诊断均在组织病理学和免疫组织化学上得到进一步证实。这些发现与细胞学的相关性很好。CMT的细胞学特征与其组织病理学和免疫组织化学特征密切相关。较新的免疫组织化学（IHC）标记多形性腺瘤基因1（PLAG1）可能有助于对细胞学和细胞块制备进行CMT的明确诊断，并具有良好的临床相关性。完全手术切除是首选的治疗方法，复发是罕见的。
