PDF(Pubmed)
Abstract：
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor that primarily affects adults, with cases in children being extremely rare. Gross total resection with subsequent irradiation and temozolomide, currently delivering the greatest overall survival, is the mainstay of therapy for juvenile GBM. Maximal surgical excision of the visible tumor mass has been shown to have a positive prognostic effect, but radiation concerns for growing brains and inconsistent results from different chemotherapy regimens in pediatric GBM make treatment choices for young patients challenging. Here, we report a case of GBM in an 11-year-old female child who presented with a dramatic presentation of neurologic deficits and clinical worsening due to rapid tumor growth.
摘要：
多形性胶质母细胞瘤（GBM）是一种侵袭性原发性脑肿瘤，主要影响成人，儿童病例极为罕见。大体全切除，随后放疗和替莫唑胺，目前提供最大的整体生存率，是青少年GBM治疗的支柱。最大限度的手术切除可见的肿瘤块已被证明具有积极的预后效果，但是,对于儿童GBM中生长的大脑的辐射担忧和不同化疗方案的不一致结果使得年轻患者的治疗选择具有挑战性.这里,我们报道了一例11岁女性儿童的GBM病例,由于肿瘤的快速生长,患者出现了严重的神经功能缺损和临床恶化.
