PDF(Pubmed)
Abstract：
BACKGROUND: This study aimed to examine the changes to choroidal blood flow velocity using laser speckle flowgraphy (LSFG) in healthy eyes after warm water immersion at 40°C.
METHODS: Data regarding the right eyes of 23 healthy volunteers were included. The mean blur rate (MBR) of the macula, which represents the choroidal blood flow velocity, was evaluated using LSFG. Intraocular pressure (IOP), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), ocular perfusion pressure (OPP), and MBR were assessed at baseline, immediately after immersion (0 minutes), and 10, 20, and 30 minutes later.
RESULTS: At 0 minutes, SBP, DBP, MBP, and OPP values were lower than those at baseline. The MBR significantly declined immediately after immersion to -6.0 ± 5.2%. However, there were no changes in these parameters after 10, 20, or 30 minutes. A significant positive correlation was observed between the MBR, SBP, DBP, MBP, and OPP values. In healthy individuals, the dominant parasympathetic activity induced by warm stimulation reduced the choroidal hemodynamic rate in the macula and decreased systemic circulatory dynamics, which normalized after 10 minutes.
CONCLUSIONS: These findings suggest that the dominant parasympathetic activity induced by warm water immersion at 40°C may lead to a reduction in the systemic circulation rate and choroidal blood flow rate in the macula. These findings may help prevent and treat various retinal choroidal diseases, in which sympathetic hyperactivity is involved in the pathogenesis of the disease.
METHODS: Data regarding the right eyes of 23 healthy volunteers were included. The mean blur rate (MBR) of the macula, which represents the choroidal blood flow velocity, was evaluated using LSFG. Intraocular pressure (IOP), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), ocular perfusion pressure (OPP), and MBR were assessed at baseline, immediately after immersion (0 minutes), and 10, 20, and 30 minutes later.
RESULTS: At 0 minutes, SBP, DBP, MBP, and OPP values were lower than those at baseline. The MBR significantly declined immediately after immersion to -6.0 ± 5.2%. However, there were no changes in these parameters after 10, 20, or 30 minutes. A significant positive correlation was observed between the MBR, SBP, DBP, MBP, and OPP values. In healthy individuals, the dominant parasympathetic activity induced by warm stimulation reduced the choroidal hemodynamic rate in the macula and decreased systemic circulatory dynamics, which normalized after 10 minutes.
CONCLUSIONS: These findings suggest that the dominant parasympathetic activity induced by warm water immersion at 40°C may lead to a reduction in the systemic circulation rate and choroidal blood flow rate in the macula. These findings may help prevent and treat various retinal choroidal diseases, in which sympathetic hyperactivity is involved in the pathogenesis of the disease.
摘要：
背景：这项研究旨在使用激光散斑血流图（LSFG）检查健康眼睛在40°C温水浸泡后脉络膜血流速度的变化。
方法：纳入了23名健康志愿者的右眼数据。黄斑的平均模糊率（MBR），代表脉络膜血流速度，使用LSFG进行评估。眼内压(IOP),收缩压（SBP），舒张压（DBP），平均血压（MBP），眼灌注压（OPP），和MBR在基线时进行评估，浸泡后立即（0分钟），10、20和30分钟后。
结果：在0分钟时，SBP,DBP,MBP,OPP值均低于基线。浸入后MBR立即显着下降至-6.0±5.2％。然而,这些参数在10,20或30分钟后没有变化.MBR之间呈显著正相关，SBP,DBP,MBP,和OPP值。在健康的个体中，热刺激诱导的显性副交感神经活动降低了黄斑脉络膜血流动力学速率，并降低了全身循环动力学，10分钟后恢复正常。
结论：这些发现表明，在40°C的温水浸泡引起的显性副交感神经活动可能导致黄斑中全身循环速率和脉络膜血流速率的降低。这些发现可能有助于预防和治疗各种视网膜脉络膜疾病，其中交感神经过度活跃与该疾病的发病机理有关。
方法：纳入了23名健康志愿者的右眼数据。黄斑的平均模糊率（MBR），代表脉络膜血流速度，使用LSFG进行评估。眼内压(IOP),收缩压（SBP），舒张压（DBP），平均血压（MBP），眼灌注压（OPP），和MBR在基线时进行评估，浸泡后立即（0分钟），10、20和30分钟后。
结果：在0分钟时，SBP,DBP,MBP,OPP值均低于基线。浸入后MBR立即显着下降至-6.0±5.2％。然而,这些参数在10,20或30分钟后没有变化.MBR之间呈显著正相关，SBP,DBP,MBP,和OPP值。在健康的个体中，热刺激诱导的显性副交感神经活动降低了黄斑脉络膜血流动力学速率，并降低了全身循环动力学，10分钟后恢复正常。
结论：这些发现表明，在40°C的温水浸泡引起的显性副交感神经活动可能导致黄斑中全身循环速率和脉络膜血流速率的降低。这些发现可能有助于预防和治疗各种视网膜脉络膜疾病，其中交感神经过度活跃与该疾病的发病机理有关。
