PDF(Pubmed)
Abstract：
BACKGROUND: Patient-controlled analgesia (PCA) is commonly used for postoperative pain control. Although widely used, intravenous (IV) morphine PCA may not be suitable for all patients. Sufentanil sublingual tablet system (SSTS) PCA is a recent technique that has had success as a safe and effective alternative for acute pain management.
OBJECTIVE: This study aims to compare both the efficacy and safety of SSTS PCA versus IV morphine PCA in postoperative pain control and the quality of recovery in adult patients following scheduled gynecological or orthopedic surgery.
METHODS: Open-label, parallel-group, randomized controlled trial with 54 patients. The primary outcome was postoperative pain control, while the secondary outcomes included adverse effects associated with two analgesic modalities, total opioid dose required, patient satisfaction, and impact on the quality of postoperative recovery.
METHODS: Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 26.0 (Released 2019; IBM Corp., Armonk, New York, United States). The chi-squared test was used in categorical variables. When distribution was normal, T-student (mean ± standard deviation) was used in continuous variables. In contrast, when distribution was not normal, the Mann-Whitney test (median (minimal-maximal)) was used.
RESULTS: The results showed that there was a statistically significant difference in the total dose of opioid used by patients at 24 hours postoperatively, with patients receiving SSTS PCA requiring a higher total dose when compared to those receiving IV morphine PCA. However, there were no statistically significant differences in pain scores, adverse events, or patient satisfaction.
CONCLUSIONS: The study suggests that both IV morphine and sublingual sufentanil are safe and effective for postoperative pain management.
OBJECTIVE: This study aims to compare both the efficacy and safety of SSTS PCA versus IV morphine PCA in postoperative pain control and the quality of recovery in adult patients following scheduled gynecological or orthopedic surgery.
METHODS: Open-label, parallel-group, randomized controlled trial with 54 patients. The primary outcome was postoperative pain control, while the secondary outcomes included adverse effects associated with two analgesic modalities, total opioid dose required, patient satisfaction, and impact on the quality of postoperative recovery.
METHODS: Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 26.0 (Released 2019; IBM Corp., Armonk, New York, United States). The chi-squared test was used in categorical variables. When distribution was normal, T-student (mean ± standard deviation) was used in continuous variables. In contrast, when distribution was not normal, the Mann-Whitney test (median (minimal-maximal)) was used.
RESULTS: The results showed that there was a statistically significant difference in the total dose of opioid used by patients at 24 hours postoperatively, with patients receiving SSTS PCA requiring a higher total dose when compared to those receiving IV morphine PCA. However, there were no statistically significant differences in pain scores, adverse events, or patient satisfaction.
CONCLUSIONS: The study suggests that both IV morphine and sublingual sufentanil are safe and effective for postoperative pain management.
摘要：
背景：患者自控镇痛（PCA）通常用于术后疼痛控制。虽然广泛使用，静脉注射(IV)吗啡PCA可能不适合所有患者.舒芬太尼舌下片系统（SSTS）PCA是一种最新技术，已成功作为急性疼痛管理的安全有效替代方法。
目的：本研究旨在比较SSTSPCA与IV吗啡PCA在妇科或骨科手术后成人患者术后疼痛控制和恢复质量方面的疗效和安全性。
方法：开放标签，平行组，54例患者的随机对照试验。主要结果是术后疼痛控制，而次要结局包括与两种镇痛方式相关的不良反应，所需的阿片类药物总剂量，患者满意度,以及对术后恢复质量的影响。
方法：使用IBMSPSSStatisticsforWindows进行统计分析，26.0版（2019年发布；IBMCorp.,Armonk,纽约,美国)。卡方检验用于分类变量。当分布正常时，在连续变量中使用T-student(平均值±标准偏差)。相比之下,当分布不正常时，使用Mann-Whitney检验(中位数(最小值-最大值))。
结果：结果表明，术后24小时患者使用的阿片类药物的总剂量存在统计学上的显着差异，与接受静脉吗啡PCA的患者相比，接受SSTSPCA的患者需要更高的总剂量。然而,疼痛评分没有统计学上的显著差异，不良事件,或患者满意度。
结论：研究表明，静脉注射吗啡和舌下舒芬太尼对于术后疼痛管理都是安全有效的。
目的：本研究旨在比较SSTSPCA与IV吗啡PCA在妇科或骨科手术后成人患者术后疼痛控制和恢复质量方面的疗效和安全性。
方法：开放标签，平行组，54例患者的随机对照试验。主要结果是术后疼痛控制，而次要结局包括与两种镇痛方式相关的不良反应，所需的阿片类药物总剂量，患者满意度,以及对术后恢复质量的影响。
方法：使用IBMSPSSStatisticsforWindows进行统计分析，26.0版（2019年发布；IBMCorp.,Armonk,纽约,美国)。卡方检验用于分类变量。当分布正常时，在连续变量中使用T-student(平均值±标准偏差)。相比之下,当分布不正常时，使用Mann-Whitney检验(中位数(最小值-最大值))。
结果：结果表明，术后24小时患者使用的阿片类药物的总剂量存在统计学上的显着差异，与接受静脉吗啡PCA的患者相比，接受SSTSPCA的患者需要更高的总剂量。然而,疼痛评分没有统计学上的显著差异，不良事件,或患者满意度。
结论：研究表明，静脉注射吗啡和舌下舒芬太尼对于术后疼痛管理都是安全有效的。
