UNASSIGNED: Seventy-six youths with a history of depression and elevated rumination were randomized to 10 to 14 sessions of RF-CBT (n = 39; 34 completers) or treatment as usual (n = 37; 28 completers). Intent-to-treat analyses assessed pre-post change in rumination response scale and in functional connectivity assessed using two 5 minute, 12 second runs of resting-state functional magnetic resonance imaging.
UNASSIGNED: We replicated previous findings: a significant reduction in rumination response scale and a reduction in left posterior cingulate cortex to right inferior frontal gyrus/inferior temporal gyrus connectivity in participants who received RF-CBT compared with those who received treatment as usual. Reductions were large (z change = 0.84; 0.73, respectively [ps < .05]).
UNASSIGNED: This adolescent clinical trial further demonstrates that depressive rumination is a brain-based mechanism that is modifiable via RF-CBT. Here, we replicated that RF-CBT reduces cross-network connectivity, a possible mechanism by which rumination becomes less frequent, intense, and automatic. This National Institute of Mental Health-funded fast-fail study continues to the R33 phase during which treatment-specific effects of RF-CBT will be compared with relaxation therapy.
■76名有抑郁和反思性升高病史的年轻人被随机分配到10至14次RF-CBT(n=39;34名完成者)或照常治疗(n=37;28名完成者)。意向治疗分析评估了反省反应量表和功能连通性的前后变化,使用两个5分钟评估,静息状态功能磁共振成像的12秒运行。
■我们重复了以前的发现:与那些接受照常治疗的患者相比,接受RF-CBT的参与者的反思性反应量表显著降低,左后扣带皮质与右下额回/颞下回的连通性降低。减少很大(z变化=0.84;0.73,分别为[ps<.05])。
■这项青少年临床试验进一步证明,抑郁反思是一种基于大脑的机制,可通过RF-CBT进行修改。这里,我们复制了RF-CBT减少了跨网络连接,一种可能的机制,通过这种机制,沉思变得不那么频繁,激烈,和自动。这项由美国国家精神卫生研究所资助的快速失败研究持续到R33阶段,在此期间,RF-CBT的治疗特异性效果将与放松疗法进行比较。