PDF(Pubmed)
Abstract：
UNASSIGNED: Clinical laboratory reference intervals play a vital role in evaluating overall well-being, tracking the progression of diseases, and detecting potential harmful effects and complications. Despite evidence revealing disparities, many African nations currently rely on reference intervals for blood analysis obtained mainly from Western populations. This practice increases the risk of misidentifying and misdiagnosing healthy individuals. The aim of this study was to establish common hematological parameters reference intervals for healthy adults in Northeast Ethiopia.
UNASSIGNED: This community-based cross-sectional study consisted of 328 individuals who were presumed to be in good health. To assess their blood-related characteristics, blood samples were collected and analyzed using the advanced Dirui BF-6500 analyzer, along with serological testing. In accordance with guidelines provided by the Clinical and Laboratory Standards Institute, the study employed a non-parametric approach to calculate the medians and 95% confidence intervals. To explore potential variations between males and females, a statistical test known as the Mann-Whitney U-test was used to compare the reference intervals.
UNASSIGNED: The established reference intervals were: white blood cells 3.5-11.3×109/L; red blood cells 4.0-6.1×1012/L; hemoglobin 11.2-17.5g/dL; hematocrit 35.4-52.0%; MCV 77.9-93.8fl; MCH 24.7-32.0pg; MCHC 306-349g/L; RDW-CV 12.1-13.8% and platelet 131-391×109/L. The reference values of monocytes, eosinophils, red blood cells, hemoglobin, hematocrit and RDW-CV in males were higher than females, while females had significantly higher platelet counts compared to males. The reference intervals discovered differed from the reference intervals now in use, those mentioned in earlier research in Ethiopia or other African nations, as well as those conducted on Western populations.
UNASSIGNED: In the adult demographic of Northeast Ethiopia, specific reference intervals for commonly observed hematological parameters were established, tailored to the local community. Consequently, these reference intervals hold the potential to enhance informed decision-making within this population, by providing valuable guidance when interpreting laboratory test outcomes.
UNASSIGNED: This community-based cross-sectional study consisted of 328 individuals who were presumed to be in good health. To assess their blood-related characteristics, blood samples were collected and analyzed using the advanced Dirui BF-6500 analyzer, along with serological testing. In accordance with guidelines provided by the Clinical and Laboratory Standards Institute, the study employed a non-parametric approach to calculate the medians and 95% confidence intervals. To explore potential variations between males and females, a statistical test known as the Mann-Whitney U-test was used to compare the reference intervals.
UNASSIGNED: The established reference intervals were: white blood cells 3.5-11.3×109/L; red blood cells 4.0-6.1×1012/L; hemoglobin 11.2-17.5g/dL; hematocrit 35.4-52.0%; MCV 77.9-93.8fl; MCH 24.7-32.0pg; MCHC 306-349g/L; RDW-CV 12.1-13.8% and platelet 131-391×109/L. The reference values of monocytes, eosinophils, red blood cells, hemoglobin, hematocrit and RDW-CV in males were higher than females, while females had significantly higher platelet counts compared to males. The reference intervals discovered differed from the reference intervals now in use, those mentioned in earlier research in Ethiopia or other African nations, as well as those conducted on Western populations.
UNASSIGNED: In the adult demographic of Northeast Ethiopia, specific reference intervals for commonly observed hematological parameters were established, tailored to the local community. Consequently, these reference intervals hold the potential to enhance informed decision-making within this population, by providing valuable guidance when interpreting laboratory test outcomes.
摘要：
■临床实验室参考间隔在评估总体健康状况中起着至关重要的作用，追踪疾病的进展，并检测潜在的有害影响和并发症。尽管有证据显示差异，许多非洲国家目前依靠参考区间进行血液分析，主要来自西方人群。这种做法增加了错误识别和误诊健康个体的风险。这项研究的目的是建立埃塞俄比亚东北部健康成年人的常见血液学参数参考区间。
■这项基于社区的横断面研究由328名被认为身体健康的人组成。为了评估他们的血液相关特征，使用先进的DiruiBF-6500分析仪收集和分析血液样本，以及血清学测试。根据临床和实验室标准研究所提供的指南，本研究采用非参数方法计算中位数和95%置信区间.为了探索男性和女性之间的潜在差异，使用称为Mann-WhitneyU检验的统计检验来比较参考区间.
■建立的参考间隔为：白细胞3.5-11.3×109/L;红细胞4.0-6.1×1012/L;血红蛋白11.2-17.5g/dL;血细胞比容35.4-52.0%;MCV77.9-93.8fl;MCH24.7-32.0pg;MCHC-349g/L;RDW-CV306-91-13.18％单核细胞的参考值，嗜酸性粒细胞,红细胞,血红蛋白,男性红细胞压积和RDW-CV高于女性，而女性的血小板计数明显高于男性。发现的参考区间与现在使用的参考区间不同，在埃塞俄比亚或其他非洲国家的早期研究中提到的那些，以及在西方人群中进行的那些。
■在埃塞俄比亚东北部的成年人口中，建立了通常观察到的血液学参数的特定参考间隔，适合当地社区。因此,这些参考区间有可能增强该人群的知情决策，通过在解释实验室测试结果时提供有价值的指导。
■这项基于社区的横断面研究由328名被认为身体健康的人组成。为了评估他们的血液相关特征，使用先进的DiruiBF-6500分析仪收集和分析血液样本，以及血清学测试。根据临床和实验室标准研究所提供的指南，本研究采用非参数方法计算中位数和95%置信区间.为了探索男性和女性之间的潜在差异，使用称为Mann-WhitneyU检验的统计检验来比较参考区间.
■建立的参考间隔为：白细胞3.5-11.3×109/L;红细胞4.0-6.1×1012/L;血红蛋白11.2-17.5g/dL;血细胞比容35.4-52.0%;MCV77.9-93.8fl;MCH24.7-32.0pg;MCHC-349g/L;RDW-CV306-91-13.18％单核细胞的参考值，嗜酸性粒细胞,红细胞,血红蛋白,男性红细胞压积和RDW-CV高于女性，而女性的血小板计数明显高于男性。发现的参考区间与现在使用的参考区间不同，在埃塞俄比亚或其他非洲国家的早期研究中提到的那些，以及在西方人群中进行的那些。
■在埃塞俄比亚东北部的成年人口中，建立了通常观察到的血液学参数的特定参考间隔，适合当地社区。因此,这些参考区间有可能增强该人群的知情决策，通过在解释实验室测试结果时提供有价值的指导。
