PDF(Pubmed)
Abstract：
Regular exercise is recommended as an important component of therapy for cardiovascular diseases in clinical practice. However, there are still major challenges in prescribing an optimized exercise regimen to individual patients with established cardiac disease. Here, we tested the effects of different exercise doses on cardiac function in mice with established myocardial infarction (MI). Exercise was introduced to mice with MI after 4 weeks of surgery. Low-dose exercise (15 min/day for 8 weeks) improved mortality and cardiac function by increasing 44.39% of ejection fractions while inhibiting fibrosis by decreasing 37.74% of distant region. Unlike higher doses of exercise, low-dose exercise consecutively upregulated cardiac expression of C1q complement/tumor necrosis factor-associated protein 9 (CTRP9) during exercise (>1.5-fold). Cardiac-specific knockdown of CTRP9 abolished the protective effects of low-dose exercise against established MI, while cardiac-specific overexpression of CTRP9 protected the heart against established MI. Mechanistically, low-dose exercise upregulated the transcription factor nuclear receptor subfamily 2 group F member 2 by increasing circulating insulin-like growth factor 1 (IGF-1), therefore, upregulating cardiac CTRP9 expression. These results suggest that low-dose exercise protects the heart against established MI via IGF-1-upregulated CTRP9 and may contribute to the development of optimized exercise prescriptions for patients with MI.
摘要：
在临床实践中，建议定期运动作为心血管疾病治疗的重要组成部分。然而,在为已确诊的心脏病患者制定优化的运动方案方面,仍存在重大挑战.这里,我们测试了不同运动剂量对心肌梗死(MI)小鼠心功能的影响.在手术4周后对患有MI的小鼠进行运动。低剂量运动（15分钟/天，持续8周）通过增加44.39％的射血分数来改善死亡率和心脏功能，同时通过减少37.74％的远处区域来抑制纤维化。与高剂量的运动不同，低剂量运动可连续上调运动期间C1q补体/肿瘤坏死因子相关蛋白9(CTRP9)的心脏表达(>1.5倍)。CTRP9的心脏特异性敲除消除了低剂量运动对既定MI的保护作用，而CTRP9的心脏特异性过表达保护心脏免受已建立的MI。机械上,低剂量运动通过增加循环胰岛素样生长因子1（IGF-1）上调转录因子核受体亚家族2组F成员2，因此,心脏CTRP9表达上调。这些结果表明，低剂量运动可通过IGF-1上调的CTRP9保护心脏免受既定的MI，并可能有助于为MI患者开发优化的运动处方。
