PDF(Pubmed)
Abstract：
Coronavirus Disease 2019 (COVID-19) is known to have various, neurological manifestations. We herein report three patients with MRI-negative myelitis following COVID-19 with abnormal somatosensory evoked potentials (SEPs). Decreased amplitude of the cortical potential and prolonged latency in the SEPs contributed to diagnosing myelitis in the present patients. The SEP findings improved as the neurological symptoms improved. Despite a delay in initiating immunosuppressive treatment after myelitis onset, all the patients improved clinically. In the light of recent progress in COVID-19 research, several hypotheses can be made to explain the pathophysiology underlying MRI-negative myelitis, including antibody-binding and microglial synapse elimination.
摘要：
2019年冠状病毒病(COVID-19)已知有多种，神经系统表现。我们在此报告了3例体感诱发电位（SEP）异常的COVID-19后MRI阴性脊髓炎患者。SEP中皮质电位幅度降低和潜伏期延长有助于诊断本患者的脊髓炎。SEP结果随着神经症状的改善而改善。尽管脊髓炎发病后开始免疫抑制治疗有所延迟，所有患者临床好转。鉴于COVID-19研究的最新进展，可以做出几个假设来解释MRI阴性脊髓炎的病理生理学，包括抗体结合和小胶质细胞突触消除。
