UNASSIGNED: In this animal study, 13 dogs were divided into three groups according to the time of sacrificing (2 months, 4 months, or 6 months). The implants were placed in oversized osteotomies, and the residual defects were filled with autograft, bovine bone graft (Cerabone), or a synthetic substitute (Osteon II). At the designated intervals, the dogs were sacrificed and the segmented implants underwent micro-computed tomography analysis. The bone-implant area (BIA) and bone-implant volume (BIV) of bone and graft material were calculated in the region of interest around the implant. The data were analyzed by two-way analysis of variance (ANOVA) at P < 0.05.
UNASSIGNED: There was no significant difference in BIA and BIV between the healing intervals for any of the grafting materials (P > 0.05). ANOVA exhibited comparable BIA and BIV between the grafting materials at 2 and 4 months after surgery (P > 0.05), although a significant difference was observed after 6 months (P < 0.05). Pairwise comparisons revealed that BIA was significantly greater in the autograft-stabilized than the synthetic-grafted sites (P = 0.035). The samples augmented with autograft also showed significantly higher BIV than those treated by the xenogenic (P = 0.017) or synthetic (P = 0.002) particles.
UNASSIGNED: All graft materials showed comparable performance in providing mineral support for implants up to 4 months after surgery. At the long-term (6-month) interval, autogenous bone demonstrated significant superiority over xenogenic and synthetic substitutes concerning the bone area and volume around the implant.
■在这项动物研究中,13只犬按牺牲时间分为三组(2个月,4个月,或6个月)。植入物被放置在过大的截骨术中,用自体移植物填充剩余的缺陷,牛骨移植物(Cerabone),或合成替代品(OsteonII)。在指定的时间间隔,处死犬,并对分段植入物进行显微计算机断层扫描分析.在植入物周围的感兴趣区域中计算骨和移植材料的骨植入物面积(BIA)和骨植入物体积(BIV)。数据采用双向方差分析(ANOVA),P<0.05。
■任何移植材料的愈合间隔之间的BIA和BIV均无显着差异(P>0.05)。术后2个月和4个月移植材料间的方差分析显示BIA和BIV具有可比性(P>0.05)。尽管6个月后观察到显着差异(P<0.05)。成对比较显示,自体移植物稳定的BIA明显高于合成移植位点(P=0.035)。用自体移植物增强的样品也显示出比由异种(P=0.017)或合成(P=0.002)颗粒处理的样品显著更高的BIV。
■所有移植材料在手术后长达4个月为植入物提供矿物质支持方面均表现出可比的性能。在长期(6个月)间隔,在植入物周围的骨面积和体积方面,自体骨显示出比异种和合成替代品的显着优势。