PDF(Pubmed)
Abstract：
Recently, the most bothersome symptom has been recommended as a co-primary endpoint in clinical trials on the acute treatment of migraine. Probable migraine is a subtype of migraine that fulfills all but one criterion for migraine diagnosis. We aimed to compare the most bothersome symptom between probable migraine and migraine. This study analyzed data from a nationwide study conducted in Korea, and the most bothersome symptom was assessed by requesting the participants to select one of the four typical accompanying symptoms of migraine. Responses to acute treatment were evaluated using the migraine Treatment Optimization Questionnaire-6. Nausea was the most bothersome symptom, followed by phonophobia and vomiting in the migraine group (nausea, 61.8%; phonophobia, 25.3%; vomiting, 10.0%; and photophobia, 2.9%) and the probable migraine group (nausea, 82.2%; phonophobia, 9.5%; vomiting, 5.6%; and photophobia, 2.7%). In participants with migraine, vomiting (adjusted odds ratio = 6.513; 95% confidence interval, 1.763-24.057) and phonophobia (adjusted odds ratio = 0.437; 95% confidence interval, 0.206-0.929) were significantly associated with severe headache intensity and nausea was significantly associated with >3 headache days per 30 days (adjusted odds ratio = 0.441; 95% confidence, 0.210-0.927). Different patterns of associations were observed in probable migraine.
摘要：
最近,在偏头痛急性治疗的临床试验中,最令人困扰的症状被推荐为共同的主要终点.可能的偏头痛是偏头痛的一种亚型，可满足偏头痛诊断的所有标准。我们旨在比较可能的偏头痛和偏头痛之间最麻烦的症状。这项研究分析了在韩国进行的一项全国性研究的数据，通过要求参与者从偏头痛的四种典型伴随症状中选择一种来评估最麻烦的症状.使用偏头痛治疗优化问卷-6评估对急性治疗的反应。恶心是最令人烦恼的症状,其次是偏头痛组的恐惧症和呕吐(恶心，61.8%；恐惧症，25.3%;呕吐,10.0%；畏光，2.9％）和可能的偏头痛组（恶心，82.2%;恐惧症,9.5%;呕吐,5.6%;畏光,2.7%）。在偏头痛的参与者中，呕吐(调整后的比值比=6.513；95%置信区间，1.763-24.057)和语音恐惧症(调整后的比值比=0.437；95%置信区间，0.206-0.929）与严重的头痛强度显着相关，而恶心与每30天>3天的头痛天数显着相关（调整后的比值比=0.441；95％的置信度，0.210-0.927）。在可能的偏头痛中观察到不同的关联模式。
