PDF(Pubmed)
Abstract：
Self-rated health (SRH) is widely recognized as a clinically significant predictor of subsequent mortality risk. Although COVID-19 may impair SRH, this relationship has not been extensively examined. The present study aimed to examine the correlation between habitual sleep duration, changes in sleep duration after infection, and SRH in subjects who have experienced SARS-CoV-2 infection.
Participants from 16 countries participated in the International COVID Sleep Study-II (ICOSS-II) online survey in 2021. A total of 10,794 of these participants were included in the analysis, including 1,509 COVID-19 individuals (who reported that they had tested positive for COVID-19). SRH was evaluated using a 0-100 linear visual analog scale. Habitual sleep durations of < 6 h and > 9 h were defined as short and long habitual sleep duration, respectively. Changes in habitual sleep duration after infection of ≤ -2 h and ≥ 1 h were defined as decreased or increased, respectively.
Participants with COVID-19 had lower SRH scores than non-infected participants, and those with more severe COVID-19 had a tendency towards even lower SRH scores. In a multivariate regression analysis of participants who had experienced COVID-19, both decreased and increased habitual sleep duration after infection were significantly associated with lower SRH after controlling for sleep quality (β = -0.056 and -0.058, respectively, both p < 0.05); however, associations between current short or long habitual sleep duration and SRH were negligible. Multinomial logistic regression analysis showed that decreased habitual sleep duration was significantly related to increased fatigue (odds ratio [OR] = 1.824, p < 0.01), shortness of breath (OR = 1.725, p < 0.05), diarrhea/nausea/vomiting (OR = 2.636, p < 0.01), and hallucinations (OR = 5.091, p < 0.05), while increased habitual sleep duration was significantly related to increased fatigue (OR = 1.900, p < 0.01).
Changes in habitual sleep duration following SARS-CoV-2 infection were associated with lower SRH. Decreased or increased habitual sleep duration might have a bidirectional relation with post-COVID-19 symptoms. Further research is needed to better understand the mechanisms underlying these relationships for in order to improve SRH in individuals with COVID-19.
Participants from 16 countries participated in the International COVID Sleep Study-II (ICOSS-II) online survey in 2021. A total of 10,794 of these participants were included in the analysis, including 1,509 COVID-19 individuals (who reported that they had tested positive for COVID-19). SRH was evaluated using a 0-100 linear visual analog scale. Habitual sleep durations of < 6 h and > 9 h were defined as short and long habitual sleep duration, respectively. Changes in habitual sleep duration after infection of ≤ -2 h and ≥ 1 h were defined as decreased or increased, respectively.
Participants with COVID-19 had lower SRH scores than non-infected participants, and those with more severe COVID-19 had a tendency towards even lower SRH scores. In a multivariate regression analysis of participants who had experienced COVID-19, both decreased and increased habitual sleep duration after infection were significantly associated with lower SRH after controlling for sleep quality (β = -0.056 and -0.058, respectively, both p < 0.05); however, associations between current short or long habitual sleep duration and SRH were negligible. Multinomial logistic regression analysis showed that decreased habitual sleep duration was significantly related to increased fatigue (odds ratio [OR] = 1.824, p < 0.01), shortness of breath (OR = 1.725, p < 0.05), diarrhea/nausea/vomiting (OR = 2.636, p < 0.01), and hallucinations (OR = 5.091, p < 0.05), while increased habitual sleep duration was significantly related to increased fatigue (OR = 1.900, p < 0.01).
Changes in habitual sleep duration following SARS-CoV-2 infection were associated with lower SRH. Decreased or increased habitual sleep duration might have a bidirectional relation with post-COVID-19 symptoms. Further research is needed to better understand the mechanisms underlying these relationships for in order to improve SRH in individuals with COVID-19.
摘要：
背景：自评估健康（SRH）被广泛认为是随后死亡风险的临床重要预测因子。尽管COVID-19可能会损害SRH，这种关系尚未得到广泛研究。本研究旨在检查习惯性睡眠持续时间之间的相关性，感染后睡眠时间的变化，和SRH在经历过SARS-CoV-2感染的受试者中。
方法：来自16个国家的参与者参加了2021年国际COVID睡眠研究-II（ICOSS-II）在线调查。共有10794名参与者被纳入分析，包括1,509名COVID-19个体（他们报告说他们的COVID-19检测呈阳性）。使用0-100线性视觉模拟量表评估SRH。<6小时和>9小时的习惯性睡眠持续时间被定义为短期和长期习惯性睡眠持续时间。分别。感染≤-2h和≥1h后习惯性睡眠持续时间的变化定义为减少或增加，分别。
结果：COVID-19参与者的SRH评分低于未感染参与者，那些患有更严重的COVID-19的人有更低的SRH评分趋势。在对经历过COVID-19的参与者的多元回归分析中，感染后习惯性睡眠时间的减少和增加与控制睡眠质量后SRH降低显着相关（β=-0.056和-0.058，两者p<0.05)；然而，目前的短期或长期习惯性睡眠持续时间与SRH之间的关联可以忽略不计.多项logistic回归分析显示,习惯性睡眠时间减少与疲劳增加显著相关(比值比[OR]=1.824,p<0.01),呼吸急促（OR=1.725，p<0.05），腹泻/恶心/呕吐（OR=2.636，p<0.01），和幻觉（OR=5.091，p<0.05），而习惯性睡眠时间的增加与疲劳的增加显着相关（OR=1.900，p<0.01）。
结论：SARS-CoV-2感染后习惯性睡眠持续时间的变化与SRH降低相关。习惯性睡眠时间减少或增加可能与COVID-19后症状有双向关系。需要进一步的研究来更好地了解这些关系的潜在机制，以改善COVID-19患者的SRH。
方法：来自16个国家的参与者参加了2021年国际COVID睡眠研究-II（ICOSS-II）在线调查。共有10794名参与者被纳入分析，包括1,509名COVID-19个体（他们报告说他们的COVID-19检测呈阳性）。使用0-100线性视觉模拟量表评估SRH。<6小时和>9小时的习惯性睡眠持续时间被定义为短期和长期习惯性睡眠持续时间。分别。感染≤-2h和≥1h后习惯性睡眠持续时间的变化定义为减少或增加，分别。
结果：COVID-19参与者的SRH评分低于未感染参与者，那些患有更严重的COVID-19的人有更低的SRH评分趋势。在对经历过COVID-19的参与者的多元回归分析中，感染后习惯性睡眠时间的减少和增加与控制睡眠质量后SRH降低显着相关（β=-0.056和-0.058，两者p<0.05)；然而，目前的短期或长期习惯性睡眠持续时间与SRH之间的关联可以忽略不计.多项logistic回归分析显示,习惯性睡眠时间减少与疲劳增加显著相关(比值比[OR]=1.824,p<0.01),呼吸急促（OR=1.725，p<0.05），腹泻/恶心/呕吐（OR=2.636，p<0.01），和幻觉（OR=5.091，p<0.05），而习惯性睡眠时间的增加与疲劳的增加显着相关（OR=1.900，p<0.01）。
结论：SARS-CoV-2感染后习惯性睡眠持续时间的变化与SRH降低相关。习惯性睡眠时间减少或增加可能与COVID-19后症状有双向关系。需要进一步的研究来更好地了解这些关系的潜在机制，以改善COVID-19患者的SRH。
