Abstract：
Herein, we present a case of a female patient with a persistent sore throat, which preceded a hypochondriacal delusion of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Both the sore throat and hypochondriacal delusion persisted together, despite the repeatedly negative results of reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 and a moderate improvement in her depression. Four possibilities for the patient\'s sore throat were discussed: pain symptoms of somatic symptom disorder, pain symptoms of depression, delusion of pain in her throat, and somatic hallucination as a sore throat. Consequently, somatic hallucinations were considered the most likely. In any case, the present findings suggest that sore throat can precede hypochondriacal delusion of SARS-CoV-2 infection in some noninfected patients. When patients continue to complain of a sore throat despite the negative results of SARS-CoV-2 by the RT-PCR test, we should consider that it might be a somatic hallucination and soon hypochondriacal delusions may occur, leading to the manifestation of other symptoms of psychiatric disorders, such as depression, which may be refractory and/or suicidal.
摘要：
■这里，我们介绍了一个女性患者持续喉咙痛的病例，在严重急性呼吸道综合症冠状病毒-2（SARS-CoV-2）感染的软骨病错觉之前。喉咙痛和软骨病妄想同时存在，尽管SARS-CoV-2的逆转录聚合酶链反应（RT-PCR）结果反复阴性，并且她的抑郁症有所改善。讨论了患者喉咙痛的四种可能性：躯体症状障碍的疼痛症状，抑郁症的疼痛症状，她喉咙疼痛的错觉，和躯体幻觉如喉咙痛。因此,躯体幻觉被认为是最有可能的。无论如何,目前的发现表明，在一些未感染的患者中，喉咙痛可以先于SARS-CoV-2感染的软骨病妄想。尽管RT-PCR检测SARS-CoV-2阴性，但患者仍抱怨喉咙痛，我们应该考虑到这可能是一种躯体幻觉，很快就会出现软骨病妄想，导致其他精神疾病症状的表现，比如抑郁症，可能是难治性和/或自杀性的。
