关键词: Nail lichen planus TNF-alpha inhibitor adverse event intralesional treatments pediatric population safety profiles systemic treatment topical therapies

Mesh : Humans Child Lichen Planus / drug therapy Immunosuppressive Agents / adverse effects Tacrolimus Calcineurin Inhibitors Adrenal Cortex Hormones / therapeutic use Administration, Topical Treatment Outcome

来  源:   DOI:10.1080/14740338.2023.2288902

Abstract:
UNASSIGNED: Topical therapies for nail lichen planus (clobetasol propionate, topical tacrolimus, bath-PUVA), intralesional treatment (triamcinolone), and systemic treatment (corticosteroids, retinoids, small molecule inhibitors (jak/stat inhibitors)), TNF-alpha inhibitors (etanercept), systemic immunomodulators (oral calcineurin inhibitors, mycophenolate mophetil), and antimalarials (chloroquine), each with unique safety profiles and considerations. Herein, we discuss common and uncommon adverse events, as well as utilization for special populations, including pregnant and pediatric patients.
摘要:
指甲扁平苔藓的局部治疗(丙酸氯倍他索,外用他克莫司,bath-PUVA),病灶内治疗(曲安奈德),和全身治疗(皮质类固醇,类维生素A,小分子抑制剂(JAK/STAT抑制剂),TNF-α抑制剂(依那西普),全身性免疫调节剂(口服钙调磷酸酶抑制剂,霉酚酸酯),和抗疟药(氯喹),每个都有独特的安全概况和注意事项。在这里,我们讨论常见和不常见的不良事件,以及特殊人群的利用,包括孕妇和儿科患者。
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