Abstract：
An 11-year-old female Persian cat underwent ovariohysterectomy due to dilation of the uterine cavity with irregular thickening of the wall. Macroscopically, the middle and distal regions of the left uterine horn were swollen and the uterine wall was irregularly thickened due to the development of multiple coalescent, variably sized nodules. Microscopically, the nodules had originated in the endometrium and were composed of round to polygonal neoplastic cells arranged in dense sheets or ill-defined fascicles. The neoplastic cells had locally invaded the myometrium and reached the subserosa, with lymphovascular invasion. Immunohistochemically, the neoplastic cell population was partially positive for CD10, an established marker of endometrial stromal sarcoma (ESS) in humans, with focal and diffuse nuclear immunopositivity for oestrogen and progesterone receptors and immunonegativity for desmin and α-smooth muscle actin. Based on these findings, the uterine tumour was diagnosed as ESS and was considered to correspond morphologically to high-grade ESS in humans.
摘要：
由于子宫腔扩张，壁不规则增厚，一只11岁的雌性波斯猫接受了卵巢子宫切除术。宏观上,由于多次合并的发展，左子宫角的中部和远端区域肿胀，子宫壁不规则增厚，大小不同的结节。微观上,结节起源于子宫内膜，由圆形至多边形的肿瘤细胞组成，这些肿瘤细胞排列在致密的薄片或模糊的束中。肿瘤细胞局部侵入子宫肌层并到达浆膜下，有淋巴管浸润.免疫组织化学，肿瘤细胞群对CD10部分呈阳性，CD10是人类子宫内膜间质肉瘤（ESS）的既定标志物，对雌激素和孕激素受体具有局灶性和弥漫性核免疫阳性，对结蛋白和α-平滑肌肌动蛋白具有免疫阴性。基于这些发现,子宫肿瘤被诊断为ESS，并被认为在形态上与人类的高级ESS相对应。
