PDF(Pubmed)
Abstract：
We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient\'s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant\'s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains.
摘要：
我们报告了一名36岁的男性患者在餐厅食用牡蛎后死于创伤弧菌引起的败血症和多器官衰竭综合征。我们从患者的血液样本中分离并鉴定了创伤弧菌vv16015，抗生素敏感性试验表明对所有21种抗生素敏感。随后从餐厅的供应商收集牡蛎样品，并分离出三株创伤弧菌。全基因组测序和分析显示，vv16015与这些菌株密切相关，并证实餐厅和供应商的海鲜中存在创伤弧菌污染。使用Galleriamelonella幼虫感染模型，确定vv16015的毒力高于从存活患者（vv15018）和牡蛎（vv220015）分离的比较菌株。深圳市创伤弧菌的人体和环境分布是零星的和异质的，与其他菌株相比，vv16015具有很高的毒力。
