METHODS: We conducted this review through a systematic search of the relevant literature using established databases such as PubMed, Scopus, and Web of Science. Selected articles were assessed, with data extracted and synthesized to provide an overview of the current understanding of the existing biomarkers for IPF.
RESULTS: Signs of epithelial cell damage hold promise as relevant biomarkers for IPF, consequently offering valuable support in its clinical care. Their global and standardized utilization remains limited due to a lack of comprehensive information of their implications in IPF.
CONCLUSIONS: Recognizing the aggressive nature of IPF among interstitial lung diseases and its profound impact on lung function and mortality, the exploration of biomarkers becomes pivotal for early diagnosis, risk assessment, prognostic evaluation, and therapy monitoring.
方法:我们通过使用已建立的数据库(如PubMed,Scopus,和WebofScience。选定的文章进行了评估,并提取和合成数据,以概述目前对IPF现有生物标志物的理解。
结果:上皮细胞损伤的迹象有望成为IPF的相关生物标志物,因此,在其临床护理中提供有价值的支持。由于缺乏有关其对IPF的影响的全面信息,因此它们的全球和标准化利用仍然有限。
结论:认识到IPF在间质性肺疾病中的侵袭性及其对肺功能和死亡率的深远影响,生物标志物的探索成为早期诊断的关键,风险评估,预后评估,和治疗监测。