PDF(Pubmed)
Abstract：
Psoriasis is an inflammatory skin disease that affects 1-2% of the general population. The pathomechanism is based on type 1 immunological reactions. Hyperplasia of the epidermis in psoriasis is a result of disrupted epidermal architecture due to increased synthesis and expression of extracellular matrix proteins. In our study, we analyzed the involvement of periostin (POSTN) in the pathogenesis of psoriasis, as one of the extracellular matrix proteins belonging to the fasciclin family. The study group consisted of 70 patients with psoriasis, while the control group comprised 30 healthy individuals. The serum concentrations of POSTN, Il-6, Il-17, Il-22, TNF-α and IFN-γ were measured in all participants. The severity of psoriasis was determined using the PASI (Psoriasis Area and Severity Index) score. The presence of POSTN in biopsy samples of 50 patients was assessed using the direct immunofluorescence method. The results were subjected to statistical analysis. The serum concentrations of POSTN, Il-6, Il-17, Il-22, TNF-α and IFN-γ in the study group are significantly higher than in the control group. Positive correlation has been demonstrated between the PASI score and the investigated cytokines, but not with POSTN. There was no statistically significant correlation between the POSTN level and the cytokines levels. POSTN deposits were localized in the epidermis in 66% of patients with psoriasis. The role of POSTN in the pathogenesis of psoriasis remains unclear. The mechanisms inducing the synthesis and expression of POSTN in psoriatic skin are not yet fully understood. Further research is needed to enhance our understanding of the mechanism underlying epidermal hyperplasia in psoriasis.
摘要：
牛皮癣是一种炎症性皮肤病，影响普通人群的1-2％。病理机制基于1型免疫反应。牛皮癣中的表皮增生是由于细胞外基质蛋白的合成和表达增加引起的表皮结构破坏的结果。在我们的研究中,我们分析了骨膜素（POSTN）在银屑病发病机制中的作用，作为fasciclin家族的细胞外基质蛋白之一。研究组由70名银屑病患者组成，对照组由30名健康个体组成。POSTN的血清浓度，在所有参与者中测量Il-6、Il-17、Il-22、TNF-α和IFN-γ。使用PASI(牛皮癣面积和严重程度指数)评分确定牛皮癣的严重程度。使用直接免疫荧光方法评估了50名患者的活检样品中POSTN的存在。对结果进行统计分析。POSTN的血清浓度，研究组IL-6、IL-17、IL-22、TNF-α和IFN-γ均明显高于对照组。已证明PASI评分与所研究的细胞因子之间存在正相关，但不是POSTN。POSTN水平与细胞因子水平之间没有统计学上的显着相关性。在66％的牛皮癣患者中，POSTN沉积物位于表皮中。POSTN在银屑病发病机制中的作用尚不清楚。在银屑病皮肤中诱导POSTN合成和表达的机制尚未完全了解。需要进一步的研究来增强我们对牛皮癣表皮增生机制的理解。
