PDF(Pubmed)
Abstract：
Lichen sclerosus (LS) is a chronic inflammatory dermatosis mostly localized in the genital area, characterized by vulvar alterations that can severely impact a patient\'s quality of life. Current treatment modalities often provide incomplete relief, and there is a need for innovative approaches to manage this condition effectively. Platelet-rich plasma (PRP) and adipose-derived stem cells (ADSCs) have emerged as potential regenerative therapies for LS, offering promising results in clinical practice. This comprehensive review explores the utilization of PRP and ADSC therapy in the treatment of genital LS, highlighting their mechanisms of action, safety profiles, and clinical outcomes. PRP is a blood product enriched in growth factors and cytokines, which promotes tissue regeneration, angiogenesis, and immune modulation. ADSC regenerative potential relies not only in their plasticity but also in the secretion of trophic factors, and modulation of the local immune response. Numerous studies have reported the safety of PRP and ADSC therapy for genital LS. Adverse events are minimal and typically involve mild, self-limiting symptoms, such as transient pain and swelling at the injection site. Long-term safety data are encouraging, with no significant concerns identified in the literature. PRP and ADSC therapy have demonstrated significant improvements in LS-related symptoms, including itching, burning, dyspareunia, and sexual function. Additionally, these therapies enable many patients to discontinue the routine use of topical corticosteroids. Several studies have explored the efficacy of combining PRP and ADSC therapy for LS. In combination, PRP and ADSCs seem to offer a synergistic approach to address the complex pathophysiology of LS, particularly in the early stages. The use of PRP and ADSC therapy for genital lichen sclerosus represents a promising and safe treatment modality. These regenerative approaches have shown significant improvements in LS-related symptoms, tissue trophism, and histological features. Combination therapy, which harnesses the synergistic effects of PRP and ADSCs, is emerging as a preferred option, especially in early-stage LS cases. Further research, including randomized controlled trials and long-term follow-up, is warranted to elucidate the full potential and mechanisms of PRP and ADSC therapy in the management of genital LS. These regenerative approaches hold great promise in enhancing the quality of life of individuals suffering from this challenging condition.
摘要：
苔藓硬化（LS）是一种慢性炎症性皮肤病，主要位于生殖器区域，以外阴改变为特征，可严重影响患者的生活质量。目前的治疗方式往往提供不完全的救济，并且需要创新的方法来有效地管理这种情况。富含血小板的血浆（PRP）和脂肪干细胞（ADSC）已成为LS的潜在再生疗法。在临床实践中提供有希望的结果。这篇全面的综述探讨了PRP和ADSC疗法在生殖器LS治疗中的应用。强调他们的行动机制，安全概况,和临床结果。PRP是富含生长因子和细胞因子的血液制品，促进组织再生，血管生成,和免疫调节。ADSC的再生潜能不仅取决于它们的可塑性，还取决于营养因子的分泌。和局部免疫反应的调节。许多研究报道了PRP和ADSC治疗生殖器LS的安全性。不良事件很少，通常涉及轻度，自我限制症状，如注射部位的短暂疼痛和肿胀。长期安全数据令人鼓舞，在文献中没有发现重大问题。PRP和ADSC治疗已显示出LS相关症状的显着改善，包括瘙痒,燃烧,性交困难,和性功能。此外,这些疗法使许多患者停止常规使用外用糖皮质激素.一些研究已经探索了联合PRP和ADSC治疗LS的功效。在组合中，PRP和ADSCs似乎提供了一种协同方法来解决LS的复杂病理生理学，特别是在早期阶段。使用PRP和ADSC治疗生殖器硬化性苔藓是一种有前途且安全的治疗方式。这些再生方法显示了LS相关症状的显着改善，组织滋养,和组织学特征。联合治疗,利用PRP和ADSCs的协同作用，正在成为首选，尤其是早期LS病例。进一步研究,包括随机对照试验和长期随访，有必要阐明PRP和ADSC治疗在生殖器LS治疗中的全部潜力和机制。这些再生方法在提高患有这种挑战性疾病的个体的生活质量方面具有很大的希望。
