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Abstract：
Interstitial lung disease and airway disease (AD) are often complicated with rheumatoid arthritis (RA) and have a poor prognosis. Several studies reported genetic associations with interstitial lung disease in RA. However, few genetic studies have examined the susceptibility to AD in RA patients. Here, we investigated whether single nucleotide variants susceptible to idiopathic pulmonary fibrosis might be associated with interstitial lung disease or AD in Japanese RA patients. Genotyping of rs2736100 [C/A] in TERT and rs1278769 [G/A] in ATP11A was conducted in 98 RA patients with usual interstitial pneumonia, 120 with nonspecific interstitial pneumonia (NSIP), 227 with AD, and 422 without chronic lung disease using TaqMan assays. An association with AD in RA was found for rs2736100 (p = 0.0043, Pc = 0.0129, odds ratio [OR] 1.40, 95% confidence interval [CI] 1.11-1.77). ATP11A rs1278769 was significantly associated with NSIP in older RA patients (>65 years, p = 0.0010, OR 2.15, 95% CI 1.35-3.40). This study first reported an association of rs2736100 with AD in RA patients and ATP11A rs1278769 with NSIP in older RA patients.
摘要：
间质性肺病和气道疾病（AD）常并发类风湿关节炎（RA），预后不良。一些研究报道了RA与间质性肺病的遗传关联。然而,很少有遗传学研究检测RA患者对AD的易感性。这里,在日本RA患者中,我们调查了对特发性肺纤维化易感的单核苷酸变异体是否与间质性肺病或AD相关.TERT中的rs2736100[C/A]和ATP11A中的rs1278769[G/A]的基因分型在98例患有普通间质性肺炎的RA患者中进行，120例非特异性间质性肺炎（NSIP），227与AD,和422使用TaqMan测定无慢性肺病。发现rs2736100与RA中的AD相关（p=0.0043，Pc=0.0129，比值比[OR]1.40，95％置信区间[CI]1.11-1.77）。ATP11Ars1278769与老年RA患者的NSIP显著相关（>65岁，p=0.0010，OR2.15，95%CI1.35-3.40）。这项研究首次报道了RA患者rs2736100与AD的相关性，以及老年RA患者ATP11Ars1278769与NSIP的相关性。
