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Abstract：
Aquaporins (AQPs) are small transmembrane proteins able to facilitate the passive transport of water and small molecules throughout cells. Several studies have demonstrated that modulation of AQPs\' expression contributes to cancer development and progression. However, to date, very little is known about their involvement in malignant melanoma (MM) progression. In this retrospective observational study, we evaluated the correlation between AQP1, -8, and -9 expression and the clinical outcomes of 58 patients diagnosed with MM from 2014 to 2016, of which 14 were diagnosed as nodular melanoma (NM) and 44 as superficial spreading melanoma (SSM). In general, we found that AQPs were more highly expressed in SSM than NM, suggesting a potential correlation with prognosis. While analyzing the expression of each AQP, we discovered that AQP1 was associated with a specific body site and low mitotic index, AQP8 with a negative sentinel lymph node, and AQP9 with the Breslow thickness and lack of ulcerations. Together with the survival analysis performed in this study, our results suggest that the expression of AQP1, -8, and -9 could be correlated with a better prognosis for malignant melanoma.
摘要：
水通道蛋白（AQP）是能够促进水和小分子在整个细胞中被动运输的小跨膜蛋白。多项研究表明，AQPs表达的调节有助于癌症的发展和进展。然而,到目前为止,关于它们与恶性黑色素瘤（MM）进展的关系知之甚少。在这项回顾性观察研究中，我们评估了2014年至2016年58例MM患者的AQP1,-8和-9表达与临床结局的相关性,其中14例诊断为结节性黑色素瘤(NM),44例诊断为浅表扩散型黑色素瘤(SSM).总的来说,我们发现AQP在SSM中的表达高于NM，提示与预后的潜在相关性。在分析每个AQP的表达时，我们发现AQP1与特定的身体部位和低有丝分裂指数有关，AQP8前哨淋巴结阴性，和AQP9与Breslow厚度和缺乏溃疡。结合本研究中进行的生存分析，我们的结果表明，AQP1，-8和-9的表达可能与恶性黑色素瘤的预后有关。
