PDF(Pubmed)
Abstract：
(1) Background: Menopause is an important event in women\'s lives, possibly contributing to the development of CVD, which is associated with changes in the cardiovascular risk profile, markers of metabolic health, and subclinical atherosclerosis. The aim of this study was to assess the association of menopause with CVD risk factors and subclinical markers of cardiometabolic disease. (2) Methods: The study involved 235 women from the general population at different stages of menopause. The methods used in this study were: diagnostic survey, anthropometric measurement (WC, height, BMI, WHtR), blood pressure measurement, biochemical analysis of venous blood (lipid profile, glucose, insulin, HbA1c), and CVD risk assessment (ASCVD Risk Calculator, POL-SCORE, SCORE-2). (3) Results: The vast majority of respondents had low cardiovascular risk, irrespective of the scale used for measuring the risk of CVD. The age at menopause was not an independent risk factor for CVD. In Model 1, the age at menopause and the time since menopause were found to be factors that increased CVD risk (OR = 1.186 and 1.267, respectively). In Models 2 and 3, the severity of menopausal symptoms was not a risk factor for CVD. Models 3 and 4 demonstrated that women with metabolic syndrome (MetS) were at a significantly higher risk of CVD. In model 5, the odds ratio of CVD with MetS as a standalone factor was 13.812. (4) Conclusions: Menopause predisposes women to an increased risk and MetS to a significantly higher risk of CVD.
摘要：
(1)背景:更年期是女性生活中的重要事件,可能有助于CVD的发展，这与心血管风险状况的变化有关，代谢健康的标志，和亚临床动脉粥样硬化。这项研究的目的是评估绝经与心血管疾病危险因素和心脏代谢疾病亚临床标志物的关系。(2)方法:本研究纳入了235名来自普通人群的处于不同绝经阶段的妇女。本研究使用的方法是：诊断调查，人体测量(WC，高度,BMI,WHtR),血压测量,静脉血的生化分析（血脂，葡萄糖，胰岛素，HbA1c），和CVD风险评估(ASCVD风险计算器，POL-SCORE,SCORE-2).(3)结果:绝大多数受访者心血管风险较低,无论用于测量CVD风险的量表如何。绝经年龄不是CVD的独立危险因素。在模型1中，发现绝经年龄和绝经以来的时间是增加CVD风险的因素（OR分别为1.186和1.267）。在模型2和模型3中，更年期症状的严重程度不是CVD的危险因素。模型3和4表明，患有代谢综合征（MetS）的女性患CVD的风险明显更高。在模型5中，以MetS为独立因子的CVD比值比为13.812。（4）结论：更年期使女性患CVD的风险增加，而MetS的风险明显更高。
