PDF(Pubmed)
Abstract：
In recent years, there has been a captivating focus of interest in elucidating the intricate crosstalk between adiponectin (APN), a versatile fat-associated adipokine and ocular pathologies. Unveiling the intricate relationship between adipocytokine APN and its receptors (AdipoRs) with aging eye disorders has emerged as a fascinating frontier in medical research. This review article delves into this connection, illuminating the hidden influence of APN on retinal health. This comprehensive review critically examines the latest findings and breakthroughs that underscore the pivotal roles of APN/AdipoRs signaling in maintaining ocular homeostasis and protecting against eye ailments. Here, we meticulously explore the intriguing mechanisms by which APN protein influences retinal function and overall visual acuity. Drawing from an extensive array of cutting-edge studies, the article highlights APN\'s multifaceted functions, ranging from anti-inflammatory properties and oxidative stress reduction to angiogenic regulation within retinal and macula tissues. The involvement of APN/AdipoRs in mediating these effects opens up novel avenues for potential therapeutic interventions targeting prevalent aging eye conditions. Moreover, this review unravels the interplay between APN signaling pathways and age-related macular degeneration (AMD). The single-cell RNA-seq results validate the expression of both the receptor isoforms (AdipoR1/R2) in retinal cells. The transcriptomic analysis showed lower expression of AdipoR1/2 in dry AMD pathogenesis compared to healthy subjects. The inhibitory adiponectin peptide (APN1) demonstrated over 75% suppression of CNV, whereas the control peptide did not exert any inhibitory effect on choroidal neovascularization (CNV). The elucidation of these relationships fosters a deeper understanding of adipose tissue\'s profound influence on ocular health, presenting new prospects for personalized treatments and preventative measures. Because APN1 inhibits CNV and leakage, it can be used to treat human AMD, although the possibility to treat human AMD is in the early stage and more clinical research is needed. In conclusion, this review provides a captivating journey into the enthralling world of APN, intertwining the realms of adipose biology and ophthalmology in aging.
摘要：
近年来,在阐明脂联素（APN），一种多功能的脂肪相关脂肪因子和眼部病变。揭示脂肪细胞因子APN及其受体（AdipoRs）与衰老眼疾之间的复杂关系已成为医学研究的迷人前沿。这篇评论文章深入研究了这一联系，阐明APN对视网膜健康的潜在影响。这篇全面的综述严格审查了最新的发现和突破，这些发现和突破强调了APN/AdipoRs信号传导在维持眼部稳态和预防眼部疾病方面的关键作用。这里,我们精心探索了APN蛋白影响视网膜功能和整体视力的有趣机制。从广泛的前沿研究中，这篇文章强调了APN的多方面功能，从抗炎特性和氧化应激减少到视网膜和黄斑组织内的血管生成调节。APN/AdipoRs参与介导这些作用为针对普遍老化的眼病的潜在治疗干预开辟了新的途径。此外，这篇综述揭示了APN信号通路与年龄相关性黄斑变性(AMD)之间的相互作用。单细胞RNA-seq结果验证了两种受体同种型(AdipoR1/R2)在视网膜细胞中的表达。转录组学分析显示,与健康受试者相比,在干性AMD发病机制中AdipoR1/2的表达较低。抑制性脂联素肽（APN1）对CNV的抑制超过75％，而对照肽对脉络膜新生血管（CNV）没有任何抑制作用。这些关系的阐明促进了对脂肪组织对眼部健康的深远影响的更深入的理解。为个性化治疗和预防措施提出了新的前景。因为APN1抑制CNV和泄漏,它可以用来治疗人类的AMD,尽管人类AMD的治疗可能性尚处于早期阶段，需要更多的临床研究。总之,这篇评论提供了一个迷人的旅程，进入迷人的APN世界，在衰老中交织在一起的脂肪生物学和眼科领域。
