PDF(Pubmed)
Abstract：
Ganoderma lucidum (G. lucidum) has been known for many centuries in Asian countries under different names, varying depending on the country. The objective of this review is to investigate the scientific research on the natural active bio-compounds in extracts obtained from G. lucidum with significant biological actions in the treatment of cancer. This review presents the classes of bio-compounds existing in G. lucidum that have been reported over time in the main databases and have shown important biological actions in the treatment of cancer. The results highlight the fact that G. lucidum possesses important bioactive compounds such as polysaccharides, triterpenoids, sterols, proteins, nucleotides, fatty acids, vitamins, and minerals, which have been demonstrated to exhibit multiple anticancer effects, namely immunomodulatory, anti-proliferative, cytotoxic, and antioxidant action. The potential health benefits of G. lucidum are systematized based on biological actions. The findings present evidence regarding the lack of certainty about the effects of G. lucidum bio-compounds in treating different forms of cancer, which may be due to the use of different types of Ganoderma formulations, differences in the study populations, or due to drug-disease interactions. In the future, larger clinical trials are needed to clarify the potential benefits of pharmaceutical preparations of G. lucidum, standardized by the known active components in the prevention and treatment of cancer.
摘要：
灵芝(G.lucidum）在亚洲国家以不同的名称闻名了许多世纪，因国家而异。这篇综述的目的是研究从灵芝提取物中获得的天然活性生物化合物的科学研究，这些提取物在癌症治疗中具有重要的生物学作用。这篇综述介绍了甘蓝中存在的生物化合物的种类，这些化合物随着时间的推移在主要数据库中被报道，并在癌症治疗中显示出重要的生物学作用。结果突出表明，灵芝具有重要的生物活性化合物，如多糖，三萜类，固醇,蛋白质，核苷酸,脂肪酸，维生素,矿物,已被证明具有多种抗癌作用，即免疫调节，抗增殖，细胞毒性，和抗氧化作用。灵芝的潜在健康益处基于生物学作用而系统化。这些发现提供了关于灵芝生物化合物在治疗不同形式的癌症中的作用缺乏确定性的证据。这可能是由于使用了不同类型的灵芝制剂，研究人群的差异，或由于药物-疾病的相互作用。在未来,需要更大的临床试验来澄清灵芝药物制剂的潜在益处，在癌症的预防和治疗中由已知的活性成分标准化。
