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Abstract：
BACKGROUND: Glomus Tumor (GT) are benign neoplasms that originate from mesenchymal cells. It presents as tenderness and cold allodynia in the digits, especially in the subungual region. There are a few studies that investigated the mechanism of pain.
OBJECTIVE: To analyze the clinical-pathologic characteristics of GT and to identify the expression of IL-1β, IL-6, and CGRP in it, further, to explore the possible mechanism of pain.
METHODS: The clinical and pathological data of 60 GT patients were retrospectively analyzed. Tissue microarrays and immunohistochemistry were used to measure the expression of IL-1β, IL-6 and CGRP.
RESULTS: GT is more common in females and the ratio of male to was near to 1:2, mostly in middle-aged people. It often occurs in fingertips, especially the thumbs. Patients often present with spontaneous pain, tenderness, and cold hypersensitivity. Both the two pain mediators IL-1β and IL-6 were highly expressed in GT cells of patients with and without cold hypersensitivity. While CGRP was not expressed in GT.
CONCLUSIONS: Low sample size and further research is needed to explore the specific mechanism.
CONCLUSIONS: IL-1β and IL-6 were highly expressed in GT cells, suggesting that IL-1β and IL-6 have certain nociceptive roles in GT. In the 4 patients with cold intolerance, the intensity of IL-1β and IL-6 staining was also strong, suggesting that they may not play a role in the cold hypersensitivity. However, since there are only 4 patients with cold intolerance, it\'s necessary to conduct further in-depth research using a larger sample size. The specific role of CGRP in GT has not been found yet.
OBJECTIVE: To analyze the clinical-pathologic characteristics of GT and to identify the expression of IL-1β, IL-6, and CGRP in it, further, to explore the possible mechanism of pain.
METHODS: The clinical and pathological data of 60 GT patients were retrospectively analyzed. Tissue microarrays and immunohistochemistry were used to measure the expression of IL-1β, IL-6 and CGRP.
RESULTS: GT is more common in females and the ratio of male to was near to 1:2, mostly in middle-aged people. It often occurs in fingertips, especially the thumbs. Patients often present with spontaneous pain, tenderness, and cold hypersensitivity. Both the two pain mediators IL-1β and IL-6 were highly expressed in GT cells of patients with and without cold hypersensitivity. While CGRP was not expressed in GT.
CONCLUSIONS: Low sample size and further research is needed to explore the specific mechanism.
CONCLUSIONS: IL-1β and IL-6 were highly expressed in GT cells, suggesting that IL-1β and IL-6 have certain nociceptive roles in GT. In the 4 patients with cold intolerance, the intensity of IL-1β and IL-6 staining was also strong, suggesting that they may not play a role in the cold hypersensitivity. However, since there are only 4 patients with cold intolerance, it\'s necessary to conduct further in-depth research using a larger sample size. The specific role of CGRP in GT has not been found yet.
摘要：
背景：血管球瘤（GT）是起源于间充质细胞的良性肿瘤。它表现为手指的压痛和冷异常性疼痛，尤其是在甲岛地区。有一些研究调查了疼痛的机制。
目的：分析GT的临床病理特征，并鉴定IL-1β的表达，IL-6和CGRP,进一步,探讨疼痛的可能机制。
方法：对60例GT患者的临床病理资料进行回顾性分析。组织芯片和免疫组织化学检测IL-1β的表达,IL-6和CGRP。
结果：GT在女性中更为常见，男性与女性的比例接近1：2，主要在中年人中。它经常发生在指尖，尤其是拇指。患者常表现为自发性疼痛，压痛,和感冒过敏。两种疼痛介质IL-1β和IL-6在有和没有冷超敏反应的患者的GT细胞中均高表达。而CGRP在GT中不表达。
结论：样本量低，需要进一步研究以探索具体机制。
结论：IL-1β和IL-6在GT细胞中高表达，提示IL-1β和IL-6在GT中具有一定的伤害性作用。在4例冷不耐受患者中，IL-1β和IL-6染色强度也很强，这表明它们可能在感冒过敏中不起作用。然而,因为只有4名患者患有冷不耐受，有必要使用更大的样本量进行进一步的深入研究。CGRP在GT中的具体作用尚未发现。
目的：分析GT的临床病理特征，并鉴定IL-1β的表达，IL-6和CGRP,进一步,探讨疼痛的可能机制。
方法：对60例GT患者的临床病理资料进行回顾性分析。组织芯片和免疫组织化学检测IL-1β的表达,IL-6和CGRP。
结果：GT在女性中更为常见，男性与女性的比例接近1：2，主要在中年人中。它经常发生在指尖，尤其是拇指。患者常表现为自发性疼痛，压痛,和感冒过敏。两种疼痛介质IL-1β和IL-6在有和没有冷超敏反应的患者的GT细胞中均高表达。而CGRP在GT中不表达。
结论：样本量低，需要进一步研究以探索具体机制。
结论：IL-1β和IL-6在GT细胞中高表达，提示IL-1β和IL-6在GT中具有一定的伤害性作用。在4例冷不耐受患者中，IL-1β和IL-6染色强度也很强，这表明它们可能在感冒过敏中不起作用。然而,因为只有4名患者患有冷不耐受，有必要使用更大的样本量进行进一步的深入研究。CGRP在GT中的具体作用尚未发现。
