Abstract：
The Kruppel-Like Factor family of regulatory proteins, which has 18 members, is transcription factors. This family contains zinc finger proteins, regulates the activation and suppression of transcription, and binds to DNA, RNA, and proteins. Klfs related to the immune system are Klf1, Klf2, Klf3, Klf4, Klf6, and Klf14. Klfs related to adipose tissue development and/or glucose metabolism are Klf3, Klf7, Klf9, Klf10, Klf11, Klf14, Klf15, and Klf16. Klfs related to cancer are Klf3, Klf4, Klf5, Klf6, Klf7, Klf8, Klf9, Klf10, Klf11, Klf12, Klf13, Klf14, Klf16, and Klf17. Klfs related to the cardiovascular system are Klf4, Klf5, Klf10, Klf13, Klf14, and Klf15. Klfs related to the nervous system are Klf4, Klf7, Klf8, and Klf9. Klfs are associated with diseases such as carcinogenesis, oxidative stress, diabetes, liver fibrosis, thalassemia, and the metabolic syndrome. The aim of this review is to provide information about the relationship of Klfs with some diseases and physiological events and to guide future studies.
摘要：
Kruppel样因子家族的调节蛋白,有18名成员，是转录因子。这个家族含有锌指蛋白，调节转录的激活和抑制，并与DNA结合，RNA,和蛋白质。与免疫系统相关的Klfl是Klfl、Klf2、Klf3、Klf4、Klf6和Klf14。与脂肪组织发育和/或葡萄糖代谢相关的Klf3、Klf7、Klf9、Klf10、Klf11、Klf14、Klf15和Klf16。与癌症相关的Klf3、Klf4、Klf5、Klf6、Klf7、Klf8、Klf9、Klf10、Klf11、Klf12、Klf13、Klf14、Klf16和Klf17。与心血管系统相关的Klf4、Klf5、Klf10、Klf13、Klf14和Klf15。与神经系统相关的Klf4、Klf7、Klf8和Klf9。Klfs与癌症发生等疾病相关，氧化应激，糖尿病,肝纤维化,地中海贫血,和代谢综合征。这篇综述的目的是提供有关Klfs与某些疾病和生理事件的关系的信息，并指导未来的研究。
