PDF(Pubmed)
Abstract：
BACKGROUND: In China, the increasing concentration of ozone (O3) has emerged as a significant air pollution issue, leading to adverse effects on public health, particularly the respiratory system. Despite the progress made in managing air pollution in China, it is crucial to address the problem of environmental O3 pollution at present.
METHODS: The connection between O3 exposure and respiratory mortality in Shenyang, China, from 2014 to 2018 was analyzed by a time-series generalized additive regression model (GAM) with quasi-Poisson regression. Additionally, the potential combined effects of fine particulate matter (PM2.5) and O3 were investigated using the synergy index (SI).
RESULTS: Our findings indicate that each 10 μg/m3 increase in O3 at lag 2 days was associated with a maximum relative risk (RR) of 1.0150 (95% CI: 1.0098-1.0202) for respiratory mortality in the total population. For individuals aged ≥55 years, unmarried individuals, those engaged in indoor occupations, and those with low educational attainment, each 10 μg/m3 increase in O3 at lag 07 days was linked to RR values of 1.0301 (95% CI: 1.0187-1.0417), 1.0437 (95% CI: 1.0266-1.0610), 1.0317 (95% CI: 1.0186-1.0450), and 1.0346 (95% CI: 1.0222-1.0471), respectively. Importantly, we discovered a synergistic effect of PM2.5 and O3, resulting in an SI of 2.372 on the occurrence of respiratory mortality.
CONCLUSIONS: This study confirmed a positive association between O3 exposure and respiratory mortality. Furthermore, it highlighted the interaction between O3 and PM2.5 in exacerbating respiratory deaths.
METHODS: The connection between O3 exposure and respiratory mortality in Shenyang, China, from 2014 to 2018 was analyzed by a time-series generalized additive regression model (GAM) with quasi-Poisson regression. Additionally, the potential combined effects of fine particulate matter (PM2.5) and O3 were investigated using the synergy index (SI).
RESULTS: Our findings indicate that each 10 μg/m3 increase in O3 at lag 2 days was associated with a maximum relative risk (RR) of 1.0150 (95% CI: 1.0098-1.0202) for respiratory mortality in the total population. For individuals aged ≥55 years, unmarried individuals, those engaged in indoor occupations, and those with low educational attainment, each 10 μg/m3 increase in O3 at lag 07 days was linked to RR values of 1.0301 (95% CI: 1.0187-1.0417), 1.0437 (95% CI: 1.0266-1.0610), 1.0317 (95% CI: 1.0186-1.0450), and 1.0346 (95% CI: 1.0222-1.0471), respectively. Importantly, we discovered a synergistic effect of PM2.5 and O3, resulting in an SI of 2.372 on the occurrence of respiratory mortality.
CONCLUSIONS: This study confirmed a positive association between O3 exposure and respiratory mortality. Furthermore, it highlighted the interaction between O3 and PM2.5 in exacerbating respiratory deaths.
摘要：
背景：在中国，不断增加的臭氧(O3)浓度已经成为一个重要的空气污染问题，对公众健康造成不良影响，尤其是呼吸系统。尽管中国在治理空气污染方面取得了进展，目前解决环境O3污染问题至关重要。
方法：沈阳地区O3暴露与呼吸道死亡率的关系，中国,从2014年到2018年，采用时间序列广义加性回归模型(GAM)与拟泊松回归进行分析。此外,使用协同指数（SI）研究了细颗粒物（PM2.5）和O3的潜在综合影响。
结果：我们的发现表明，滞后2天时O3每增加10μg/m3，总人群中呼吸道死亡的最大相对风险（RR）为1.0150（95％CI：1.0098-1.0202）。对于年龄≥55岁的个人，未婚人士,从事室内职业的人，那些受教育程度低的人，滞后07天时O3的每10μg/m3增加与1.0301的RR值相关(95%CI:1.0187-1.0417)，1.0437（95%CI：1.0266-1.0610），1.0317（95%CI：1.0186-1.0450），和1.0346（95%CI：1.0222-1.0471），分别。重要的是,我们发现PM2.5和O3的协同作用，导致SI为2.372对呼吸系统死亡的发生。
结论：这项研究证实了O3暴露与呼吸道死亡率之间的正相关。此外，它强调了O3和PM2.5之间的相互作用加剧了呼吸道死亡。
方法：沈阳地区O3暴露与呼吸道死亡率的关系，中国,从2014年到2018年，采用时间序列广义加性回归模型(GAM)与拟泊松回归进行分析。此外,使用协同指数（SI）研究了细颗粒物（PM2.5）和O3的潜在综合影响。
结果：我们的发现表明，滞后2天时O3每增加10μg/m3，总人群中呼吸道死亡的最大相对风险（RR）为1.0150（95％CI：1.0098-1.0202）。对于年龄≥55岁的个人，未婚人士,从事室内职业的人，那些受教育程度低的人，滞后07天时O3的每10μg/m3增加与1.0301的RR值相关(95%CI:1.0187-1.0417)，1.0437（95%CI：1.0266-1.0610），1.0317（95%CI：1.0186-1.0450），和1.0346（95%CI：1.0222-1.0471），分别。重要的是,我们发现PM2.5和O3的协同作用，导致SI为2.372对呼吸系统死亡的发生。
结论：这项研究证实了O3暴露与呼吸道死亡率之间的正相关。此外，它强调了O3和PM2.5之间的相互作用加剧了呼吸道死亡。
