METHODS: The connection between O3 exposure and respiratory mortality in Shenyang, China, from 2014 to 2018 was analyzed by a time-series generalized additive regression model (GAM) with quasi-Poisson regression. Additionally, the potential combined effects of fine particulate matter (PM2.5) and O3 were investigated using the synergy index (SI).
RESULTS: Our findings indicate that each 10 μg/m3 increase in O3 at lag 2 days was associated with a maximum relative risk (RR) of 1.0150 (95% CI: 1.0098-1.0202) for respiratory mortality in the total population. For individuals aged ≥55 years, unmarried individuals, those engaged in indoor occupations, and those with low educational attainment, each 10 μg/m3 increase in O3 at lag 07 days was linked to RR values of 1.0301 (95% CI: 1.0187-1.0417), 1.0437 (95% CI: 1.0266-1.0610), 1.0317 (95% CI: 1.0186-1.0450), and 1.0346 (95% CI: 1.0222-1.0471), respectively. Importantly, we discovered a synergistic effect of PM2.5 and O3, resulting in an SI of 2.372 on the occurrence of respiratory mortality.
CONCLUSIONS: This study confirmed a positive association between O3 exposure and respiratory mortality. Furthermore, it highlighted the interaction between O3 and PM2.5 in exacerbating respiratory deaths.
方法:沈阳地区O3暴露与呼吸道死亡率的关系,中国,从2014年到2018年,采用时间序列广义加性回归模型(GAM)与拟泊松回归进行分析。此外,使用协同指数(SI)研究了细颗粒物(PM2.5)和O3的潜在综合影响。
结果:我们的发现表明,滞后2天时O3每增加10μg/m3,总人群中呼吸道死亡的最大相对风险(RR)为1.0150(95%CI:1.0098-1.0202)。对于年龄≥55岁的个人,未婚人士,从事室内职业的人,那些受教育程度低的人,滞后07天时O3的每10μg/m3增加与1.0301的RR值相关(95%CI:1.0187-1.0417),1.0437(95%CI:1.0266-1.0610),1.0317(95%CI:1.0186-1.0450),和1.0346(95%CI:1.0222-1.0471),分别。重要的是,我们发现PM2.5和O3的协同作用,导致SI为2.372对呼吸系统死亡的发生。
结论:这项研究证实了O3暴露与呼吸道死亡率之间的正相关。此外,它强调了O3和PM2.5之间的相互作用加剧了呼吸道死亡。