PDF(Pubmed)
Abstract：
Male breast cancer (BC) represents less than 1% of male tumors. Little is known about male BC characteristics, management, and survival, with many studies based on a small number of cases. Consequently, the treatment of male BC lacks specific guidelines. The aims of the study are to compare male and female breast cancer (FBC) in terms of cancer clinical and anatomopathological features and treatment approach, and to identify differences between male BC and FBC in terms of survival. Patients and methods: Data from 2006 to 2018 were retrospectively acquired. Amounts of 49 males and 680 postmenopausal females with primary non-metastatic BC who underwent breast surgery at Mauriziano Hospital or IRCCS Candiolo (TO-Italy) were included. The mean age at diagnosis for male BC was 68.6 years, and males presented a smaller tumor size than women (p < 0.05) at diagnosis. Most male BC patients received adjuvant endocrine therapy (AET) with tamoxifen (73.5%). AET drop-out rate due to side effects was 16.3% for males compared to 7.6% for women (p = 0.04). Comparing FBC and male BC, no differences have been identified in terms of DFS and OS, with a similar 10-year-relapse rate (12% male BC vs. 12.4% FBC). Propensity Score Matching by age, nodal status, pT, and molecular subtype had been performed and no differences in OS and DFS were seen between male BC and FBC. In conclusion, male BC and FBC have similar prognostic factors and survival outcomes. The drop-out rate of AET was higher in males, and side effects were the main reason for drug discontinuation.
摘要：
男性乳腺癌（BC）占男性肿瘤的不到1％。对男性BC特征知之甚少，管理,和生存，许多研究基于少数病例。因此,男性BC的治疗缺乏具体的指南。这项研究的目的是比较男性和女性乳腺癌（FBC）在癌症的临床和解剖病理学特征和治疗方法，并确定男性BC和FBC在存活率方面的差异。患者和方法：回顾性获得了2006年至2018年的数据。包括在Mauriziano医院或IRCCSCandiolo（TO-Italy）接受乳房手术的49名男性和680名绝经后女性原发性非转移性BC。诊断为男性BC的平均年龄为68.6岁，男性在诊断时肿瘤体积比女性小(p<0.05)。大多数男性BC患者接受他莫昔芬辅助内分泌治疗（AET）（73.5％）。由于副作用引起的AET辍学率男性为16.3％，而女性为7.6％（p=0.04）。比较FBC和男性BC，在DFS和OS方面没有发现任何差异，具有相似的10年复发率（男性BC与12％12.4%FBC）。按年龄匹配的倾向得分，节点状态，pT,并且已经进行了分子亚型，男性BC和FBC之间的OS和DFS没有差异。总之,男性BC和FBC具有相似的预后因素和生存结局.男性AET的辍学率较高，副作用是停药的主要原因。
