PDF(Pubmed)
Abstract：
Chronic pulmonary aspergillosis (CPA) is a chronic progressive lung disease associated with a poor prognosis and a 5-year mortality rate of approximately 40-50%. The disease is characterized by slowly progressive destruction of the lung parenchyma, in the form of multiple cavities, nodules, infiltrates or fibrosis. CPA can be challenging to diagnose due to its non-specific symptoms and similarities with other respiratory conditions combined with the poor awareness of the medical community about the disease. This can result in delayed treatment even for years and worsening of the patient\'s condition. Serological tests certainly play a significant role in diagnosing CPA but cannot be interpreted without radiological confirmation of CPA. Although many data are published on this hot topic, there is yet no single definitive test for diagnosing CPA, and a multidisciplinary approach which involves a combination of clinical picture, radiological findings, microbiological results and exclusion of other mimicking diseases, is essential for the accurate diagnosis of CPA.
摘要：
慢性肺曲霉病（CPA）是一种慢性进行性肺病，预后差，5年死亡率约为40-50％。该疾病的特征是肺实质的缓慢进行性破坏，以多个空腔的形式，结节,浸润或纤维化。由于其非特异性症状以及与其他呼吸系统疾病的相似性，再加上医学界对该疾病的认识不足，CPA可能具有挑战性。这可能导致延迟治疗甚至多年和恶化的病人的条件。血清学检查在诊断CPA中肯定起着重要作用，但如果没有CPA的放射学确认，则无法解释。尽管关于这个热门话题发表了许多数据，诊断注册会计师还没有单一的明确测试，和多学科方法，涉及临床图片的组合，放射学发现，微生物学结果和排除其他模拟疾病，对于CPA的准确诊断至关重要。
