PDF(Pubmed)
Abstract：
(1) Introduction: Current evidence shows that mechanical debridement augmented with systemic and topical antibiotics may be beneficial for the treatment of peri-implantitis. The microbial profile of peri-implantitis plays a key role in identifying the most suitable antibiotics to be used for the treatment and prevention of peri-implantitis. This systematic review aimed to summarize and critically analyze the methodology and findings of studies which have utilized sequencing techniques to elucidate the microbial profiles of peri-implantitis. (2) Results: Fusobacterium, Treponema, and Porphyromonas sp. are associated with peri-implantitis. Veillonella sp. are associated with healthy implant sites and exhibit a reduced prevalence in deeper pockets and with greater severity of disease progression. Streptococcus sp. have been identified both in diseased and healthy sites. Neisseria sp. have been associated with healthy implants and negatively correlate with the probing depth. Methanogens and AAGPRs were also detected in peri-implantitis sites. (3) Methods: The study was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023459266). The PRISMA criteria were used to select articles retrieved from a systematic search of the Scopus, Cochrane, and Medline databases until 1 August 2023. Title and abstract screening was followed by a full-text review of the included articles. Thirty-two articles were included in the final qualitative analysis. (4) Conclusions: A distinct microbial profile could not be identified from studies employing sequencing techniques to identify the microbiome. Further studies are needed with more standardization to allow a comparison of findings. A universal clinical parameter for the diagnosis of peri-implantitis should be implemented in all future studies to minimize confounding factors. The subject pool should also be more diverse and larger to compensate for individual differences, and perhaps a distinct microbial profile can be seen with a larger sample size.
摘要：
（1）简介：目前的证据表明，全身和局部抗生素增强的机械清创可能对种植体周围炎的治疗有益。种植体周围炎的微生物谱在确定用于治疗和预防种植体周围炎的最合适的抗生素中起着关键作用。本系统综述旨在总结和批判性地分析利用测序技术阐明种植体周炎微生物谱的研究方法和结果。（2）结果：梭杆菌，密螺旋体,和卟啉单胞菌sp.与种植体周围炎有关.Veillonellasp.与健康的植入部位相关，在较深的口袋中患病率降低，疾病进展的严重程度更高。链球菌。已在患病和健康部位被发现。奈瑟菌sp.与健康的植入物有关，与探测深度呈负相关。在种植体周围炎部位也检测到产甲烷菌和AAGPR。（3）方法：本研究已在国际前瞻性系统审查注册中心（PROSPERO）（CRD42023459266）注册。PRISMA标准用于选择从Scopus的系统搜索中检索到的文章，科克伦,和Medline数据库，直到2023年8月1日。标题和摘要筛选后，对所包含的文章进行了全文审查。最终的定性分析包括32篇文章。(4)结论:从使用测序技术来鉴定微生物组的研究中不能鉴定出不同的微生物谱。需要进行更多标准化的进一步研究，以比较研究结果。在未来的所有研究中，应实施诊断种植体周围炎的通用临床参数，以最大程度地减少混杂因素。主题池也应该更多样化和更大，以弥补个体差异，也许可以用更大的样本量看到不同的微生物谱。
