PDF(Pubmed)
Abstract：
OBJECTIVE: Vitamin K2 (VK2) is an essential co-factor for bone metabolism. There is still very little data regarding possible VK2 relation to periodontitis. This study aimed to investigate any potential link between VK2 serum level and the severity of periodontitis in comparison to a control group of healthy individuals. The trial was performed on 100 patients among whom 50 were diagnosed with periodontitis. The patients underwent full clinical periodontal and radiological examination. The VK2 serum level was assessed using the ELISA kit (Gla-type osteocalcin EIA Kit, Takara, Kusatsu). Patients with periodontitis had mean serum levels of VK2 significantly lower (0.27 ± 0.06 nmol/L; p < 0.001) than the control group (0.43 ± 0.09 nmol/L; p < 0.001) regardless of the patient\'s age or sex. The VK2 serum level decreased with the severity of periodontitis with the lowest level in stage IV of the disease (0.19 ± 0.01 nmol/L; p < 0.001). Also, a significant drop was noticed between the grades of periodontitis. Individuals with localized forms of the disease had significantly lower VK2 levels (0.26 ± 0.006 nmol/L; p < 0.001) in comparison to subjects with generalized periodontitis (0.30 ± 0.01 nmol/L; p < 0.001). The VK2 serum levels were also associated with most of the clinical parameters such as bleeding on probing (-0.805, 95% CI: -0.894 to -0.654, p < 0.001), attachment loss (-0.752, 95% CI: -0.862 to -0.574, p < 0.001), and bone loss (-0.656, 95% CI: -0.801 to -0.439, p < 0.001). In the present study, the VK2 serum level was correlated to periodontitis, and its severity, complexity, extension, and grade. The range of VK2 was decreasing together with the worsening of all clinical parameters of periodontitis.
摘要：
目的：维生素K2（VK2）是骨代谢的重要辅助因子。关于VK2可能与牙周炎有关的数据仍然很少。这项研究旨在调查与健康个体对照组相比，VK2血清水平与牙周炎严重程度之间的任何潜在联系。该试验对100例患者进行，其中50例被诊断为牙周炎。患者接受了全面的临床牙周和放射学检查。采用ELISA试剂盒(Gla型骨钙蛋白EIA试剂盒,Takara,草松）。无论患者的年龄或性别如何，牙周炎患者的平均血清VK2水平（0.27±0.06nmol/L；p<0.001）均明显低于对照组（0.43±0.09nmol/L；p<0.001）。血清VK2水平随着牙周炎的严重程度而降低，在疾病的IV期最低（0.19±0.01nmol/L；p<0.001）。此外，在牙周炎的等级之间发现了明显的下降。与患有全身性牙周炎的受试者（0.30±0.01nmol/L；p<0.001）相比，患有局部疾病的个体的VK2水平显着降低（0.26±0.006nmol/L；p<0.001）。VK2血清水平也与大多数临床参数相关，例如探查出血（-0.805，95％CI：-0.894至-0.654，p<0.001），附着损失（-0.752，95%CI：-0.862至-0.574，p<0.001），骨丢失（-0.656，95%CI：-0.801至-0.439，p<0.001）。在本研究中,VK2血清水平与牙周炎相关，和它的严重性，复杂性，扩展,和等级。随着牙周炎所有临床参数的恶化，VK2的范围逐渐减小。
