Abstract：
In recent years, dysregulation of the notch pathway has been associated with the development and progression of various cancers. Notch signaling is involved in several cellular processes such as proliferation, differentiation, apoptosis, and angiogenesis, and its abnormal activation can lead to uncontrolled cell growth and tumorigenesis. In various cancers, the Notch pathway has been shown to have both tumor-promoting and tumor-suppressive effects, depending on the context and stage of cancer development. In some cases, activation of the Notch pathway has been shown to promote tumor growth and progression, while in others it has been shown to inhibit tumor growth and induce cell death. The Notch pathway has been found to be particularly important in the development of leukaemia, breast cancer, lung cancer and pancreatic cancer. In leukaemia, the Notch pathway is often activated, which promotes the survival and proliferation of leukaemia cells. In breast cancer, Notch signaling has been implicated in tumor initiation and maintenance of cancer stem cells. In cervical cancer, the Notch signaling pathway has been shown to play a crucial role in the development of the disease. In lung cancer, Notch activation promotes cancer cell proliferation and migration, while in pancreatic cancer, Notch signaling is associated with tumor initiation and resistance to chemotherapy. Understanding the role of the Notch pathway in cancer development and progression may provide new opportunities for the development of targeted therapies for cancer treatment. Several drugs targeting the Notch pathway are currently in preclinical or clinical development and may hold promise for anticancer therapy in the future.
摘要：
近年来,notch通路的失调与各种癌症的发展和进展有关。Notch信号参与几种细胞过程，如增殖，分化,凋亡，和血管生成，其异常激活可导致细胞生长和肿瘤发生失控。在各种癌症中，Notch通路已被证明具有促进肿瘤和抑制肿瘤的作用，取决于癌症发展的背景和阶段。在某些情况下,Notch通路的激活已被证明可以促进肿瘤的生长和进展，而在其他方面，它已被证明可以抑制肿瘤生长并诱导细胞死亡。已发现Notch通路在白血病的发展中特别重要，乳腺癌,肺癌和胰腺癌。在白血病中，Notch通路经常被激活,促进白血病细胞的存活和增殖。在乳腺癌中，Notch信号传导与肿瘤启动和癌症干细胞的维持有关。在宫颈癌中，Notch信号通路已被证明在疾病的发展中起着至关重要的作用。在肺癌中，Notch激活促进癌细胞增殖和迁移，而在胰腺癌中，Notch信号与肿瘤启动和对化疗的抗性有关。了解Notch通路在癌症发展和进展中的作用可能为开发用于癌症治疗的靶向疗法提供新的机会。靶向Notch途径的几种药物目前处于临床前或临床开发中，并且可能在未来有望用于抗癌治疗。
