PDF(Pubmed)
Abstract：
OBJECTIVE: Lumbar spine disorders have become an increasingly common health problem in recent years. Modern clinical studies have shown that perioperative analgesia at certain doses can reduce postoperative pain by inhibiting the process of peripheral sensitization and central sensitization, which is also known as \"preemptive analgesia,\" Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs that achieve antipyretic and analgesic effects by inhibiting cyclooxygenase (COX) and affecting the production of prostaglandins. Our meta-analysis aimed to assess the efficacy and safety of perioperative preemptive analgesia with non-steroidal anti-inflammatory drugs in patients with lumbar spine surgery.
METHODS: We searched PubMed, ScienceDirect, the Cochrane Library, and the Web of Science for randomized controlled trials (RCTs) that met the inclusion criteria. A total of 12 clinical studies were included to assess the efficacy and safety of perioperative NSAIDs preemptive analgesia for lumbar spine surgery.
RESULTS: Twelve studies, including 845 patients, met the inclusion criteria. The results showed that perioperative receipt of NSAIDs for preemptive analgesia was effective and safe. Patient\'s postoperative morphine consumption (P < 0.05), visual analog scale (P < 0.05), and numerical rating scale (P < 0.05) were not statistically associated with postoperative complications (P > 0.05).
CONCLUSIONS: Our findings suggest that NSAIDs are effective and safe for preemptive analgesia in the perioperative period of lumbar spine surgery and that more and better quality RCTs and more in-depth studies of pain mechanics are still needed.
METHODS: We searched PubMed, ScienceDirect, the Cochrane Library, and the Web of Science for randomized controlled trials (RCTs) that met the inclusion criteria. A total of 12 clinical studies were included to assess the efficacy and safety of perioperative NSAIDs preemptive analgesia for lumbar spine surgery.
RESULTS: Twelve studies, including 845 patients, met the inclusion criteria. The results showed that perioperative receipt of NSAIDs for preemptive analgesia was effective and safe. Patient\'s postoperative morphine consumption (P < 0.05), visual analog scale (P < 0.05), and numerical rating scale (P < 0.05) were not statistically associated with postoperative complications (P > 0.05).
CONCLUSIONS: Our findings suggest that NSAIDs are effective and safe for preemptive analgesia in the perioperative period of lumbar spine surgery and that more and better quality RCTs and more in-depth studies of pain mechanics are still needed.
摘要：
目的：近年来，腰椎疾病已成为越来越常见的健康问题。现代临床研究表明,一定剂量的围手术期镇痛可通过抑制外周致敏和中枢致敏过程减轻术后疼痛,这也被称为“先发制人镇痛，“非甾体抗炎药（NSAIDs）是一类通过抑制环氧合酶（COX）并影响前列腺素的产生而达到解热和镇痛作用的药物。我们的荟萃分析旨在评估非甾体抗炎药在腰椎手术患者围手术期超前镇痛的有效性和安全性。
方法：我们搜索了PubMed，ScienceDirect,Cochrane图书馆,以及符合纳入标准的WebofScience随机对照试验（RCTs）。共纳入12项临床研究，以评估腰椎手术围手术期NSAIDs超前镇痛的有效性和安全性。
结果：12项研究，包括845名病人,符合纳入标准。结果表明，围手术期接受NSAIDs超前镇痛是有效和安全的。患者术后吗啡消耗量（P<0.05），视觉模拟量表(P<0.05)，数值评定量表(P<0.05)与术后并发症无统计学相关性(P>0.05)。
结论：我们的研究结果表明，非甾体抗炎药在腰椎手术围手术期的超前镇痛是有效和安全的，仍需要更多和更好的质量RCT和更深入的疼痛力学研究。
方法：我们搜索了PubMed，ScienceDirect,Cochrane图书馆,以及符合纳入标准的WebofScience随机对照试验（RCTs）。共纳入12项临床研究，以评估腰椎手术围手术期NSAIDs超前镇痛的有效性和安全性。
结果：12项研究，包括845名病人,符合纳入标准。结果表明，围手术期接受NSAIDs超前镇痛是有效和安全的。患者术后吗啡消耗量（P<0.05），视觉模拟量表(P<0.05)，数值评定量表(P<0.05)与术后并发症无统计学相关性(P>0.05)。
结论：我们的研究结果表明，非甾体抗炎药在腰椎手术围手术期的超前镇痛是有效和安全的，仍需要更多和更好的质量RCT和更深入的疼痛力学研究。
