METHODS: We searched PubMed, ScienceDirect, the Cochrane Library, and the Web of Science for randomized controlled trials (RCTs) that met the inclusion criteria. A total of 12 clinical studies were included to assess the efficacy and safety of perioperative NSAIDs preemptive analgesia for lumbar spine surgery.
RESULTS: Twelve studies, including 845 patients, met the inclusion criteria. The results showed that perioperative receipt of NSAIDs for preemptive analgesia was effective and safe. Patient\'s postoperative morphine consumption (P < 0.05), visual analog scale (P < 0.05), and numerical rating scale (P < 0.05) were not statistically associated with postoperative complications (P > 0.05).
CONCLUSIONS: Our findings suggest that NSAIDs are effective and safe for preemptive analgesia in the perioperative period of lumbar spine surgery and that more and better quality RCTs and more in-depth studies of pain mechanics are still needed.
方法:我们搜索了PubMed,ScienceDirect,Cochrane图书馆,以及符合纳入标准的WebofScience随机对照试验(RCTs)。共纳入12项临床研究,以评估腰椎手术围手术期NSAIDs超前镇痛的有效性和安全性。
结果:12项研究,包括845名病人,符合纳入标准。结果表明,围手术期接受NSAIDs超前镇痛是有效和安全的。患者术后吗啡消耗量(P<0.05),视觉模拟量表(P<0.05),数值评定量表(P<0.05)与术后并发症无统计学相关性(P>0.05)。
结论:我们的研究结果表明,非甾体抗炎药在腰椎手术围手术期的超前镇痛是有效和安全的,仍需要更多和更好的质量RCT和更深入的疼痛力学研究。