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Abstract：
BACKGROUND: This study aimed to compare the effect of two preservative-free (PF) artificial tears, one containing carboxymethylcellulose (CMC) (control group) vs another containing hyaluronic acid and hydroxypropyl guar (HA + HP-guar) (study group), on the healing of the corneal epithelium and the ocular discomfort after bilateral photorefractive keratectomy (PRK) surgery.
METHODS: A total of 68 patients that were scheduled to have PRK to correct myopia were randomized into two groups: 34 patients (68 eyes) in the study group and 34 patients (68 eyes) in the control group. Ocular examinations were performed on postoperative days 1, 4, 7, 30, and 90, evaluating the diameter of the de-epithelized cornea, the fluorescein staining using the Oxford scale, the tear film osmolarity and stability (tear breakup time), and the pain using visual analog scale (VAS).
RESULTS: On postoperative day 4, 97% of the study eyes vs 84.4% of the control eyes were completely re-epithelized (p = 0.01). Less ocular pain was observed on postoperative day 3 in the study group (5.0 (3.0-6.0) vs 6.0 (3.5-7.0), p = 0.03). No differences were observed beyond postoperative day 7 in the healing of the corneal epithelium, non-invasive Keratograph breakup time (NIKBUT), and the self-perceived ocular discomfort between the two groups.
CONCLUSIONS: The current study shows faster healing of the corneal epithelium and less ocular pain and discomfort in the first days after PRK with the use of topical lubricants containing HA + HP-guar compared to conventional CMC artificial tears, probably due to the different trophic effect of the aforementioned tears on the corneal epithelial cells.
BACKGROUND: EudraCT No. 2020-003488-25.
METHODS: A total of 68 patients that were scheduled to have PRK to correct myopia were randomized into two groups: 34 patients (68 eyes) in the study group and 34 patients (68 eyes) in the control group. Ocular examinations were performed on postoperative days 1, 4, 7, 30, and 90, evaluating the diameter of the de-epithelized cornea, the fluorescein staining using the Oxford scale, the tear film osmolarity and stability (tear breakup time), and the pain using visual analog scale (VAS).
RESULTS: On postoperative day 4, 97% of the study eyes vs 84.4% of the control eyes were completely re-epithelized (p = 0.01). Less ocular pain was observed on postoperative day 3 in the study group (5.0 (3.0-6.0) vs 6.0 (3.5-7.0), p = 0.03). No differences were observed beyond postoperative day 7 in the healing of the corneal epithelium, non-invasive Keratograph breakup time (NIKBUT), and the self-perceived ocular discomfort between the two groups.
CONCLUSIONS: The current study shows faster healing of the corneal epithelium and less ocular pain and discomfort in the first days after PRK with the use of topical lubricants containing HA + HP-guar compared to conventional CMC artificial tears, probably due to the different trophic effect of the aforementioned tears on the corneal epithelial cells.
BACKGROUND: EudraCT No. 2020-003488-25.
摘要：
背景：本研究旨在比较两种无防腐剂（PF）人工泪液的效果，一种含有羧甲基纤维素（CMC）（对照组）与另一种含有透明质酸和羟丙基瓜尔胶（HAHP-瓜尔胶）（研究组），双侧屈光性角膜切削术（PRK）手术后角膜上皮的愈合和眼部不适。
方法：将68例接受PRK矫正近视的患者随机分为两组：研究组34例（68只眼）和对照组34例（68只眼）。术后第1、4、7、30和90天进行眼部检查，评估去上皮角膜的直径，使用牛津量表的荧光素染色，泪膜渗透压和稳定性（撕裂破裂时间），疼痛采用视觉模拟量表(VAS)。
结果：在术后第4天，97％的研究眼和84.4％的对照眼完全重新上皮化（p=0.01）。研究组术后第3天眼部疼痛减轻（5.0（3.0-6.0）vs6.0（3.5-7.0），p=0.03)。术后第7天角膜上皮愈合无差异,非侵入性角膜造影破裂时间（NIKBUT），以及两组之间自我感知的眼部不适。
结论：目前的研究表明，与常规CMC人工泪液相比，PRK术后第一天使用含有HA+HP-瓜尔胶的局部润滑剂，角膜上皮愈合更快，眼部疼痛和不适更少。可能是由于上述眼泪对角膜上皮细胞的营养作用不同。
背景：EudraCTNo.2020-003488-25。
方法：将68例接受PRK矫正近视的患者随机分为两组：研究组34例（68只眼）和对照组34例（68只眼）。术后第1、4、7、30和90天进行眼部检查，评估去上皮角膜的直径，使用牛津量表的荧光素染色，泪膜渗透压和稳定性（撕裂破裂时间），疼痛采用视觉模拟量表(VAS)。
结果：在术后第4天，97％的研究眼和84.4％的对照眼完全重新上皮化（p=0.01）。研究组术后第3天眼部疼痛减轻（5.0（3.0-6.0）vs6.0（3.5-7.0），p=0.03)。术后第7天角膜上皮愈合无差异,非侵入性角膜造影破裂时间（NIKBUT），以及两组之间自我感知的眼部不适。
结论：目前的研究表明，与常规CMC人工泪液相比，PRK术后第一天使用含有HA+HP-瓜尔胶的局部润滑剂，角膜上皮愈合更快，眼部疼痛和不适更少。可能是由于上述眼泪对角膜上皮细胞的营养作用不同。
背景：EudraCTNo.2020-003488-25。
