All patients who had undergone omental biopsy at our institution from January 2010 to December 2018 and had a tissue diagnosis of PC or PTB were eligible for inclusion. Patients who did not have a contrast-enhanced CT abdomen within one month of the omental biopsy were excluded. A region of interest (ROI) was manually drawn over omental lesions and radiomic features were extracted using open-source LIFEx software. Statistical analysis was performed to compare mean differences in CT texture parameters between the PC and PTB groups.
A total of 66 patients were included in the study of which 38 and 28 had PC and PTB, respectively. Omental lesions in patients with PC had higher mean radiodensity (mean difference: +32.4; p = 0.001), higher mean entropy (mean difference: +0.11; p < 0.001), and lower mean energy (mean difference: -0.024; p = 0.001) compared to those in PTB. Additionally, omental lesions in the PC group had lower gray-level co-occurrence matrix (GLCM) homogeneity (mean difference: -0.073; p < 0.001) and higher GLCM dissimilarity (mean difference: +0.480; p < 0.001) as compared to the PTB group.
CT texture parameters of omental lesions differed significantly between patients with PTB and those with PC, which may help clinicians in differentiating between the two entities.
方法:2010年1月至2018年12月在我们机构接受网膜活检且组织诊断为PC或PTB的所有患者均可纳入。排除在大网膜活检后一个月内未进行对比增强CT腹部检查的患者。在网膜病变上手动绘制感兴趣区域(ROI),并使用开源LIFEx软件提取影像组学特征。进行统计学分析以比较PC组和PTB组之间CT纹理参数的平均差异。
结果:本研究共纳入66例患者,其中38例和28例患有PC和PTB,分别。PC患者的Omental病变具有较高的平均放射密度(平均差异:32.4;p=0.001),较高的平均熵(平均差:+0.11;p<0.001),与PTB相比,平均能量较低(平均差:-0.024;p=0.001)。此外,与PTB组相比,PC组的网膜病变具有较低的灰度共生矩阵(GLCM)同质性(平均差:-0.073;p<0.001)和较高的GLCM相异性(平均差:0.480;p<0.001)。
结论:PTB患者和PC患者的网膜病变的CT纹理参数有显著差异,这可能有助于临床医生区分这两个实体。