时间进化揭示了侵袭性神经内分泌小细胞前列腺癌转分化中的分叉谱系。
关键词: ASCL1 ASCL2 POU2F3, TFAP4 cancer lineage plasticity neuroendocrine prostate small cell stem-like trans-differentiation
Mesh : Male Humans Lung Neoplasms / genetics Carcinoma, Small Cell / genetics Transcription Factors / genetics Prostatic Neoplasms / genetics pathology Cell Transdifferentiation / genetics Basic Helix-Loop-Helix Transcription Factors / genetics metabolism Gene Expression Regulation, Neoplastic Cell Line, Tumor Small Cell Lung Carcinoma / genetics
来 源:
DOI:10.1016/j.ccell.2023.10.009
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