Abstract：
To investigate whether the induction-to-expulsion interval during second-trimester medication abortion in pregnancies complicated by anencephaly or other fetal anomalies is prolonged compared to pregnancies without fetal anomalies STUDY DESIGN: This was a retrospective cohort study of women who had second-trimester medication abortion at St. Paul\'s Hospital Millennium Medical College (Addis Ababa, Ethiopia). We assigned subjects to one of three groups based on fetal diagnosis: 1) anencephaly group, 2) other congenital anomaly group, and 3) no anomaly group. Data were collected by reviewing patients\' charts. We used SPSS version 23 to analyze the data. Simple descriptive analysis and χ2 test were performed as appropriate.
A total of 303 women had second-trimester medication at 14-28 weeks, of which 58 had anencephaly, 19 had congenital anomalies other than anencephaly, and the remaining 226 had no fetal anomalies. The mean induction-to-expulsion interval was 18.4 hours in the anencephaly group versus 19.4 hours in the other congenital anomaly group versus 19.2 hours in those without anomaly (p-value = 0.924). The 24-hour nonexpulsion rate was also comparable among the groups, with 5.25% rate of nonexpulsion in the anencephaly group versus 15.8% in the other congenital anomaly group versus 11.15% in the no anomaly group (p-value = 0.594). In multivariable regression analysis after controlling for parity, the 24-hour nonexpulsion rate was not significantly different.
In this study, pregnancies undergoing second-trimester medication abortion for fetal anomalies had comparable induction-to-expulsion interval and 24-hour expulsion rates compared to those who had the same procedure for other or no anomalies.
Second-trimester medication abortion procedure length in pregnancies complicated by anencephaly is similar to those pregnancies without anomalies.
A total of 303 women had second-trimester medication at 14-28 weeks, of which 58 had anencephaly, 19 had congenital anomalies other than anencephaly, and the remaining 226 had no fetal anomalies. The mean induction-to-expulsion interval was 18.4 hours in the anencephaly group versus 19.4 hours in the other congenital anomaly group versus 19.2 hours in those without anomaly (p-value = 0.924). The 24-hour nonexpulsion rate was also comparable among the groups, with 5.25% rate of nonexpulsion in the anencephaly group versus 15.8% in the other congenital anomaly group versus 11.15% in the no anomaly group (p-value = 0.594). In multivariable regression analysis after controlling for parity, the 24-hour nonexpulsion rate was not significantly different.
In this study, pregnancies undergoing second-trimester medication abortion for fetal anomalies had comparable induction-to-expulsion interval and 24-hour expulsion rates compared to those who had the same procedure for other or no anomalies.
Second-trimester medication abortion procedure length in pregnancies complicated by anencephaly is similar to those pregnancies without anomalies.
摘要：
目的：调查与无胎儿畸形的妊娠相比，在妊娠中期药物流产合并无脑畸形或其他胎儿畸形的妊娠中，引产至驱逐间隔是否延长。研究设计：这是一项回顾性队列研究，研究妇女在圣保罗医院千年医学院（亚的斯亚贝巴，埃塞俄比亚)。我们根据胎儿诊断将受试者分为三组之一：1）无脑组2）其他先天性异常组3）无异常组。通过查看患者图表收集数据。我们使用SPSS版本23来分析数据。适当时进行简单的描述性分析和卡方检验。
结果：共有303名妇女在14-28周时接受了孕中期药物治疗，其中58人患有无脑症，19人患有无脑以外的先天性异常，其余226例没有胎儿异常.各组之间的诱导至排出间隔没有差异。无脑组的平均诱导排出间隔为18.4小时，其他先天性异常组的19.4小时与无异常者为19.2小时(p值=0.924)。两组的24小时不驱逐率也相当,无脑畸形组无排出率为5.25%，其他先天性异常组为15.8%，无异常组为11.15%，（p值=0.594）。在控制平差后的多变量回归分析中，24小时非排出率无显著差异.
结论：在这项研究中，与对其他异常或无异常进行相同手术的妊娠患者相比,因胎儿异常而进行孕中期药物流产的妊娠患者的诱导间期至逐出间期和24小时逐出率相当.
结论：妊娠合并无脑畸形的妊娠中期药物流产手术长度与无异常妊娠相似。
■本研究期间生成或分析的所有数据均包含在此发表的文章中。
结果：共有303名妇女在14-28周时接受了孕中期药物治疗，其中58人患有无脑症，19人患有无脑以外的先天性异常，其余226例没有胎儿异常.各组之间的诱导至排出间隔没有差异。无脑组的平均诱导排出间隔为18.4小时，其他先天性异常组的19.4小时与无异常者为19.2小时(p值=0.924)。两组的24小时不驱逐率也相当,无脑畸形组无排出率为5.25%，其他先天性异常组为15.8%，无异常组为11.15%，（p值=0.594）。在控制平差后的多变量回归分析中，24小时非排出率无显著差异.
结论：在这项研究中，与对其他异常或无异常进行相同手术的妊娠患者相比,因胎儿异常而进行孕中期药物流产的妊娠患者的诱导间期至逐出间期和24小时逐出率相当.
结论：妊娠合并无脑畸形的妊娠中期药物流产手术长度与无异常妊娠相似。
■本研究期间生成或分析的所有数据均包含在此发表的文章中。
