关键词: Pancreatic cancer carbon dots dendrimers liposomes nano-formulations nanotechnology patents tumor -microenvironment

Mesh : Humans Liposomes / therapeutic use Drug Delivery Systems Nanotubes, Carbon Patents as Topic Nanoparticles Nanotechnology Pancreatic Neoplasms / drug therapy

来  源:   DOI:10.1080/13543776.2023.2287520

Abstract:
UNASSIGNED: Nanotechnology may open up new avenues for overcoming the challenges of pancreatic cancer therapy as a broad arsenal of anticancer medicines fail to realize their full therapeutic potential in pancreatic ductal adenocarcinoma due to the formation of multiple resistance mechanisms inside the tumor. Many studies have reported the successful use of various nano formulations in pancreatic cancer therapy.
UNASSIGNED: This review covers all the major nanotechnology-based patent litrature available on renowned patent data bases like Patentscope and Espacenet, through the time period of 2007-2022. This is an entirely patent centric review, and it includes both clinical and non-clinical data available on nanotechnology-based therapeutics and diagnostic tools for pancreatic cancer.
UNASSIGNED: For the sake of understanding, the patents are categorized under various formulation-specific heads like metallic/non-metallic nanoparticles, polymeric nanoparticles, liposomes, carbon nanotubes, protein nanoparticles and liposomes. This distinguishes one specific nanoparticle type from another and makes this review a one-of-a-kind comprehensive patent compilation that has not been reported so far in the history of nanotechnological formulations in pancreatic cancer.
摘要:
纳米技术可能为克服胰腺癌治疗的挑战开辟新的途径,因为广泛的抗癌药物库由于在胰腺导管腺癌中形成多种耐药机制而无法实现其在胰腺导管腺癌中的全部治疗潜力。肿瘤。许多研究报道了各种纳米制剂在胰腺癌治疗中的成功使用。
这篇综述涵盖了在著名专利数据库(如Patentscope和Espacenet)上提供的所有主要的基于纳米技术的专利文献,在2007-2022年期间。这是一个完全以专利为中心的综述,它包括基于纳米技术的胰腺癌治疗和诊断工具的临床和非临床数据。
为了理解,这些专利被归类为各种配方特定的头部,如金属/非金属纳米颗粒,聚合物纳米颗粒,脂质体,碳纳米管,蛋白质纳米颗粒和脂质体。这将一种特定的纳米颗粒类型与另一种纳米颗粒类型区分开来,并使这篇综述成为一种综合专利汇编,迄今为止,在胰腺癌纳米技术制剂的历史上尚未报道。
公众号