PDF(Pubmed)
Abstract：
The purpose of this study was to explore echocardiographic parameters of the left ventricle (LV) in relation to the outcomes of omphalocele neonates with pulmonary hypertension (PH).
This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. Patients in this study did not have additional severe malformations or chromosomal aberrations. Patients who died under palliative care were excluded. The echocardiographic parameters of LV were obtained within 24 h after birth. Clinical and outcomes data were recorded, echocardiograms evaluated for left ventricular internal dimension in end-diastole (LVIDd), end-diastolic volume (EDV), stroke volume (SV) and cardiac output index (CI), among others.
There were 18 omphalocele newborns with PH, of whom 14 survived and 4 died. Both groups were comparable in the baseline characteristics. Non-survival was associated with a smaller LV [LVIDd (12.2 mm versus15.7 mm, p < 0.05), EDV (3.5 ml versus 6.8 ml, p < 0.05)] and with worse systolic function [SV (2.3 ml versus 4.2 ml, p < 0.05), and CI (1.7 L/min/m2 versus 2.9 L/min/m2, p < 0.01)].
In the cohort of omphalocele patients with PH, lower LVIDd, EDV, SV and CI were associated with mortality.
Level III.
This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. Patients in this study did not have additional severe malformations or chromosomal aberrations. Patients who died under palliative care were excluded. The echocardiographic parameters of LV were obtained within 24 h after birth. Clinical and outcomes data were recorded, echocardiograms evaluated for left ventricular internal dimension in end-diastole (LVIDd), end-diastolic volume (EDV), stroke volume (SV) and cardiac output index (CI), among others.
There were 18 omphalocele newborns with PH, of whom 14 survived and 4 died. Both groups were comparable in the baseline characteristics. Non-survival was associated with a smaller LV [LVIDd (12.2 mm versus15.7 mm, p < 0.05), EDV (3.5 ml versus 6.8 ml, p < 0.05)] and with worse systolic function [SV (2.3 ml versus 4.2 ml, p < 0.05), and CI (1.7 L/min/m2 versus 2.9 L/min/m2, p < 0.01)].
In the cohort of omphalocele patients with PH, lower LVIDd, EDV, SV and CI were associated with mortality.
Level III.
摘要：
目的：本研究的目的是探讨左心室（LV）超声心动图参数与伴有肺动脉高压（PH）的新生儿脐膨出的关系。
方法：这项回顾性研究是在2019年至2020年出生的PH患者中进行的。这项研究中的患者没有其他严重的畸形或染色体畸变。在姑息治疗下死亡的患者被排除在外。在出生后24小时内获得LV的超声心动图参数。记录临床和结果数据，超声心动图评估左心室舒张末期内径（LVIDd），舒张末期容积(EDV),每搏输出量（SV）和心输出量指数（CI），在其他人中。
结果：有18例脐膨出新生儿PH，其中14人幸存，4人死亡。两组在基线特征方面具有可比性。非生存与较小的LV[LVIDd（12.2mm对15.7mm，p<0.05)，EDV（3.5ml对6.8ml，p<0.05）]和收缩功能较差[SV（2.3ml对4.2ml，p<0.05)，和CI（1.7L/min/m2对2.9L/min/m2，p<0.01）]。
结论：在患有PH的脐膨出患者的队列中，较低的LVIDd,EDV,SV和CI与死亡率相关。
方法：三级。
方法：这项回顾性研究是在2019年至2020年出生的PH患者中进行的。这项研究中的患者没有其他严重的畸形或染色体畸变。在姑息治疗下死亡的患者被排除在外。在出生后24小时内获得LV的超声心动图参数。记录临床和结果数据，超声心动图评估左心室舒张末期内径（LVIDd），舒张末期容积(EDV),每搏输出量（SV）和心输出量指数（CI），在其他人中。
结果：有18例脐膨出新生儿PH，其中14人幸存，4人死亡。两组在基线特征方面具有可比性。非生存与较小的LV[LVIDd（12.2mm对15.7mm，p<0.05)，EDV（3.5ml对6.8ml，p<0.05）]和收缩功能较差[SV（2.3ml对4.2ml，p<0.05)，和CI（1.7L/min/m2对2.9L/min/m2，p<0.01）]。
结论：在患有PH的脐膨出患者的队列中，较低的LVIDd,EDV,SV和CI与死亡率相关。
方法：三级。
