Abstract：
BACKGROUND: Medical syringes are widely used in hospitals to store and administer drugs, and the contact time between the drugs and these syringes can vary from a few minutes to several weeks like for pharmaceutical preparations. The aim of this comparative study was to evaluate the potential sorption phenomena occurring between three drugs (paracetamol, diazepam and insulin aspart) and polypropylene syringes (PP) or syringes made of Cyclic Olefin Copolymer (COC).
METHODS: 50 mL 3-part syringes made of either COC with crosslinked silicone on the barrel inner surface (COC-CLS) and a bromobutyl plunger seal, or PP lubricated with silicone oil (PP-SOL) with a polyisoprene plunger seal were used.
RESULTS: COC-CLS syringes induced less sorption of diazepam and insulin than PP-SOL syringes and the plunger seal material seemed to be the main cause of these interactions. An alkalinization of the medications in contact with the PP-SOL syringes was observed. It could be caused by leachable compounds and should be investigated further.
CONCLUSIONS: This work shows once again that it is essential to consider content-container interactions to help improve the safe use of parenteral drugs.
METHODS: 50 mL 3-part syringes made of either COC with crosslinked silicone on the barrel inner surface (COC-CLS) and a bromobutyl plunger seal, or PP lubricated with silicone oil (PP-SOL) with a polyisoprene plunger seal were used.
RESULTS: COC-CLS syringes induced less sorption of diazepam and insulin than PP-SOL syringes and the plunger seal material seemed to be the main cause of these interactions. An alkalinization of the medications in contact with the PP-SOL syringes was observed. It could be caused by leachable compounds and should be investigated further.
CONCLUSIONS: This work shows once again that it is essential to consider content-container interactions to help improve the safe use of parenteral drugs.
摘要：
背景：医用注射器在医院中广泛用于存储和管理药物，药物和这些注射器之间的接触时间可以从几分钟到几周不等，就像药物制剂一样。这项比较研究的目的是评估三种药物（扑热息痛，地西泮和门冬胰岛素）和聚丙烯注射器（PP）或由环烯烃共聚物（COC）制成的注射器。
方法：由COC制成的50mL3部分注射器，其中COC内表面带有交联有机硅（COC-CLS）和溴丁基柱塞密封，或使用带有聚异戊二烯柱塞密封件的硅油（PP-SOL）润滑的PP。
结果：与PP-SOL注射器相比，COC-CLS注射器诱导地西泮和胰岛素的吸收较少，柱塞密封材料似乎是这些相互作用的主要原因。观察到与PP-SOL注射器接触的药物的碱化。它可能是由可浸出的化合物引起的，应该进一步研究。
结论：这项工作再次表明，必须考虑内容物-容器的相互作用，以帮助提高肠胃外药物的安全使用。
方法：由COC制成的50mL3部分注射器，其中COC内表面带有交联有机硅（COC-CLS）和溴丁基柱塞密封，或使用带有聚异戊二烯柱塞密封件的硅油（PP-SOL）润滑的PP。
结果：与PP-SOL注射器相比，COC-CLS注射器诱导地西泮和胰岛素的吸收较少，柱塞密封材料似乎是这些相互作用的主要原因。观察到与PP-SOL注射器接触的药物的碱化。它可能是由可浸出的化合物引起的，应该进一步研究。
结论：这项工作再次表明，必须考虑内容物-容器的相互作用，以帮助提高肠胃外药物的安全使用。
