Abstract：
BACKGROUND: Noninvasive body contouring is becoming more popular in the United States as an alternative to liposuction. The most popular of these methods, cryolipolysis, uses precisely controlled cooling to reduce focal adiposities. The number of cryolipolysis procedures performed annually has experienced rampant growth in United States markets, and the indications have likewise diversified. In light of this change, it is imperative to perform an updated review of available US safety and efficacy data on cryolipolysis.
OBJECTIVE: To examine the safety and efficacy of cryolipolysis treatments in the United States using data extracted from research performed exclusively at US-based sites.
METHODS: In order to identify relevant studies, a literature search was conducted on PubMed using the terms \"CoolSculpting\" OR \"cryolipolysis\" OR \"lipocryolysis.\" Articles were manually reviewed to exclude literature reviews, research not performed on humans, studies on experimental combinations of techniques, and any studies not performed in the United States.
RESULTS: The initial literature search returned 246 results. Following manual review, a total of 18 studies were selected for data extraction. Mean reduction in fat thickness by ultrasound was 2.0-5.1 mm or 19.6%-32.3%; mean reduction by body caliper was 2.3-7 mm or 14.9%-21.5%. Side effects were mild and transient. Four instances of PAH were documented in 3453 treatment cycles.
CONCLUSIONS: Cryolipolysis is a safe, modestly effective method for reducing focal adiposity. Complications are rare and treatable. However, US-based studies are few in number and often of low power and/or quality. More high-quality research is needed for all aspects of cryolipolysis.
OBJECTIVE: To examine the safety and efficacy of cryolipolysis treatments in the United States using data extracted from research performed exclusively at US-based sites.
METHODS: In order to identify relevant studies, a literature search was conducted on PubMed using the terms \"CoolSculpting\" OR \"cryolipolysis\" OR \"lipocryolysis.\" Articles were manually reviewed to exclude literature reviews, research not performed on humans, studies on experimental combinations of techniques, and any studies not performed in the United States.
RESULTS: The initial literature search returned 246 results. Following manual review, a total of 18 studies were selected for data extraction. Mean reduction in fat thickness by ultrasound was 2.0-5.1 mm or 19.6%-32.3%; mean reduction by body caliper was 2.3-7 mm or 14.9%-21.5%. Side effects were mild and transient. Four instances of PAH were documented in 3453 treatment cycles.
CONCLUSIONS: Cryolipolysis is a safe, modestly effective method for reducing focal adiposity. Complications are rare and treatable. However, US-based studies are few in number and often of low power and/or quality. More high-quality research is needed for all aspects of cryolipolysis.
摘要：
背景：在美国，非侵入性身体轮廓作为吸脂术的替代方法越来越受欢迎。这些方法中最流行的，冷冻脂解,使用精确控制的冷却来减少局灶性肥胖。每年进行的冷冻脂解手术的数量在美国市场经历了迅猛的增长，迹象也同样多样化。鉴于这种变化，我们必须对美国现有的冷冻脂肪分解安全性和有效性数据进行更新审查.
目的：使用从专门在美国进行的研究中提取的数据，来检查美国冷冻脂解治疗的安全性和有效性。
方法：为了确定相关研究，在PubMed上使用术语\"CoolSculpting\"或\"冷冻溶脂\"或\"脂质体溶解进行文献检索。“文章进行了手动审查，以排除文献审查，没有对人类进行研究，技术的实验组合研究，以及未在美国进行的任何研究。
结果：最初的文献检索返回了246个结果。手动审核后，共选取18项研究进行数据提取.超声检查脂肪厚度平均减少2.0-5.1mm或19.6％-32.3％；身体卡尺平均减少2.3-7mm或14.9％-21.5％。副作用是轻微和短暂的。在3453个治疗周期中记录了4例PAH。
结论：低温溶酶是一种安全的，减少局灶性肥胖的适度有效方法。并发症是罕见且可治疗的。然而,基于美国的研究数量很少，通常是低功率和/或质量的。对于冷冻脂解的各个方面都需要更多高质量的研究。
目的：使用从专门在美国进行的研究中提取的数据，来检查美国冷冻脂解治疗的安全性和有效性。
方法：为了确定相关研究，在PubMed上使用术语\"CoolSculpting\"或\"冷冻溶脂\"或\"脂质体溶解进行文献检索。“文章进行了手动审查，以排除文献审查，没有对人类进行研究，技术的实验组合研究，以及未在美国进行的任何研究。
结果：最初的文献检索返回了246个结果。手动审核后，共选取18项研究进行数据提取.超声检查脂肪厚度平均减少2.0-5.1mm或19.6％-32.3％；身体卡尺平均减少2.3-7mm或14.9％-21.5％。副作用是轻微和短暂的。在3453个治疗周期中记录了4例PAH。
结论：低温溶酶是一种安全的，减少局灶性肥胖的适度有效方法。并发症是罕见且可治疗的。然而,基于美国的研究数量很少，通常是低功率和/或质量的。对于冷冻脂解的各个方面都需要更多高质量的研究。
